Subclinical Signs of Retinal Involvement in Hereditary Angioedema

To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healt...

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Autores principales:	Paola Triggianese, Matteo Di Marino, Carolina Nesi, Elisabetta Greco, Stella Modica, Maria Sole Chimenti, Paola Conigliaro, Raffaele Mancino, Carlo Nucci, Massimo Cesareo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	complement system hereditary angioedema retina OCT OCT-A Medicine R
Acceso en línea:	https://doaj.org/article/5bb7077dc87441f48c40c0bacf46dafd
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spelling	oai:doaj.org-article:5bb7077dc87441f48c40c0bacf46dafd2021-11-25T18:02:35ZSubclinical Signs of Retinal Involvement in Hereditary Angioedema10.3390/jcm102254152077-0383https://doaj.org/article/5bb7077dc87441f48c40c0bacf46dafd2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5415https://doaj.org/toc/2077-0383To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healthy subjects (HC). All participants underwent SD-OCT-scanning of retinal posterior pole (PP), peripapillary retinal nerve fiber layer (pRNFL), and optic nerve head (ONH). Superficial/deep capillary density was analyzed by OCT-A. A total of 80 eyes from 40 HAE and 40 eyes from HC were evaluated. The pRNFL was thicker in HAE than in HC in nasal superior (<i>p</i> < 0.0001) and temporal quadrants (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right). The ONH thickness in HAE patients was greater than in HC in the nasal (<i>p</i> = 0.008 left, <i>p</i> = 0.01 right), temporal (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right), temporal inferior (<i>p</i> = 0.007 left, <i>p</i> = 0.0008 right), and global (<i>p</i> = 0.005 left, <i>p</i> = 0.007 right) scans. Compared to HC, HAE showed a lower capillary density in both superficial (<i>p</i> = 0.001 left, <i>p</i> = 0.006 right) and deep (<i>p</i> = 0.008 left, <i>p</i> = 0.004 right) whole images, and superficial (<i>p</i> = 0.03 left) and deep parafoveal (<i>p</i> = 0.007 left, <i>p</i> = 0.005 right) areas. Our findings documented subclinical retinal abnormalities in type I HAE, supporting a potential role of the retinal assessment by SD-OCT/OCT-A as a useful tool in the comprehensive care of HAE patients.Paola TriggianeseMatteo Di MarinoCarolina NesiElisabetta GrecoStella ModicaMaria Sole ChimentiPaola ConigliaroRaffaele MancinoCarlo NucciMassimo CesareoMDPI AGarticlecomplement systemhereditary angioedemaretinaOCTOCT-AMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5415, p 5415 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	complement system hereditary angioedema retina OCT OCT-A Medicine R
spellingShingle	complement system hereditary angioedema retina OCT OCT-A Medicine R Paola Triggianese Matteo Di Marino Carolina Nesi Elisabetta Greco Stella Modica Maria Sole Chimenti Paola Conigliaro Raffaele Mancino Carlo Nucci Massimo Cesareo Subclinical Signs of Retinal Involvement in Hereditary Angioedema
description	To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healthy subjects (HC). All participants underwent SD-OCT-scanning of retinal posterior pole (PP), peripapillary retinal nerve fiber layer (pRNFL), and optic nerve head (ONH). Superficial/deep capillary density was analyzed by OCT-A. A total of 80 eyes from 40 HAE and 40 eyes from HC were evaluated. The pRNFL was thicker in HAE than in HC in nasal superior (<i>p</i> < 0.0001) and temporal quadrants (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right). The ONH thickness in HAE patients was greater than in HC in the nasal (<i>p</i> = 0.008 left, <i>p</i> = 0.01 right), temporal (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right), temporal inferior (<i>p</i> = 0.007 left, <i>p</i> = 0.0008 right), and global (<i>p</i> = 0.005 left, <i>p</i> = 0.007 right) scans. Compared to HC, HAE showed a lower capillary density in both superficial (<i>p</i> = 0.001 left, <i>p</i> = 0.006 right) and deep (<i>p</i> = 0.008 left, <i>p</i> = 0.004 right) whole images, and superficial (<i>p</i> = 0.03 left) and deep parafoveal (<i>p</i> = 0.007 left, <i>p</i> = 0.005 right) areas. Our findings documented subclinical retinal abnormalities in type I HAE, supporting a potential role of the retinal assessment by SD-OCT/OCT-A as a useful tool in the comprehensive care of HAE patients.
format	article
author	Paola Triggianese Matteo Di Marino Carolina Nesi Elisabetta Greco Stella Modica Maria Sole Chimenti Paola Conigliaro Raffaele Mancino Carlo Nucci Massimo Cesareo
author_facet	Paola Triggianese Matteo Di Marino Carolina Nesi Elisabetta Greco Stella Modica Maria Sole Chimenti Paola Conigliaro Raffaele Mancino Carlo Nucci Massimo Cesareo
author_sort	Paola Triggianese
title	Subclinical Signs of Retinal Involvement in Hereditary Angioedema
title_short	Subclinical Signs of Retinal Involvement in Hereditary Angioedema
title_full	Subclinical Signs of Retinal Involvement in Hereditary Angioedema
title_fullStr	Subclinical Signs of Retinal Involvement in Hereditary Angioedema
title_full_unstemmed	Subclinical Signs of Retinal Involvement in Hereditary Angioedema
title_sort	subclinical signs of retinal involvement in hereditary angioedema
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5bb7077dc87441f48c40c0bacf46dafd
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Subclinical Signs of Retinal Involvement in Hereditary Angioedema

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