Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases

Chronic inflammation promotes endothelial plasticity, leading to the development of several diseases, including fibrosis and cancer in numerous organs. The basis of those processes is a phenomenon called the endothelial–mesenchymal transition (EndMT), which results in the delamination of tightly con...

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Autores principales:	Wojciech Michał Ciszewski, Marta Ewelina Wawro, Izabela Sacewicz-Hofman, Katarzyna Sobierajska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	EndMT cancer fibrosis cytoskeleton remodeling Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5bb7deb19e25482da305c32390fd2eda
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spelling	oai:doaj.org-article:5bb7deb19e25482da305c32390fd2eda2021-11-11T17:05:03ZCytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases10.3390/ijms2221116071422-00671661-6596https://doaj.org/article/5bb7deb19e25482da305c32390fd2eda2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11607https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chronic inflammation promotes endothelial plasticity, leading to the development of several diseases, including fibrosis and cancer in numerous organs. The basis of those processes is a phenomenon called the endothelial–mesenchymal transition (EndMT), which results in the delamination of tightly connected endothelial cells that acquire a mesenchymal phenotype. EndMT-derived cells, known as the myofibroblasts or cancer-associated fibroblasts (CAFs), are characterized by the loss of cell–cell junctions, loss of endothelial markers, and gain in mesenchymal ones. As a result, the endothelium ceases its primary ability to maintain patent and functional capillaries and induce new blood vessels. At the same time, it acquires the migration and invasion potential typical of mesenchymal cells. The observed modulation of cell shape, increasedcell movement, and invasion abilities are connected with cytoskeleton reorganization. This paper focuses on the review of current knowledge about the molecular pathways involved in the modulation of each cytoskeleton element (microfilaments, microtubule, and intermediate filaments) during EndMT and their role as the potential targets for cancer and fibrosis treatment.Wojciech Michał CiszewskiMarta Ewelina WawroIzabela Sacewicz-HofmanKatarzyna SobierajskaMDPI AGarticleEndMTcancerfibrosiscytoskeleton remodelingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11607, p 11607 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	EndMT cancer fibrosis cytoskeleton remodeling Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	EndMT cancer fibrosis cytoskeleton remodeling Biology (General) QH301-705.5 Chemistry QD1-999 Wojciech Michał Ciszewski Marta Ewelina Wawro Izabela Sacewicz-Hofman Katarzyna Sobierajska Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
description	Chronic inflammation promotes endothelial plasticity, leading to the development of several diseases, including fibrosis and cancer in numerous organs. The basis of those processes is a phenomenon called the endothelial–mesenchymal transition (EndMT), which results in the delamination of tightly connected endothelial cells that acquire a mesenchymal phenotype. EndMT-derived cells, known as the myofibroblasts or cancer-associated fibroblasts (CAFs), are characterized by the loss of cell–cell junctions, loss of endothelial markers, and gain in mesenchymal ones. As a result, the endothelium ceases its primary ability to maintain patent and functional capillaries and induce new blood vessels. At the same time, it acquires the migration and invasion potential typical of mesenchymal cells. The observed modulation of cell shape, increasedcell movement, and invasion abilities are connected with cytoskeleton reorganization. This paper focuses on the review of current knowledge about the molecular pathways involved in the modulation of each cytoskeleton element (microfilaments, microtubule, and intermediate filaments) during EndMT and their role as the potential targets for cancer and fibrosis treatment.
format	article
author	Wojciech Michał Ciszewski Marta Ewelina Wawro Izabela Sacewicz-Hofman Katarzyna Sobierajska
author_facet	Wojciech Michał Ciszewski Marta Ewelina Wawro Izabela Sacewicz-Hofman Katarzyna Sobierajska
author_sort	Wojciech Michał Ciszewski
title	Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
title_short	Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
title_full	Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
title_fullStr	Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
title_full_unstemmed	Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
title_sort	cytoskeleton reorganization in endmt—the role in cancer and fibrotic diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5bb7deb19e25482da305c32390fd2eda
work_keys_str_mv	AT wojciechmichałciszewski cytoskeletonreorganizationinendmttheroleincancerandfibroticdiseases AT martaewelinawawro cytoskeletonreorganizationinendmttheroleincancerandfibroticdiseases AT izabelasacewiczhofman cytoskeletonreorganizationinendmttheroleincancerandfibroticdiseases AT katarzynasobierajska cytoskeletonreorganizationinendmttheroleincancerandfibroticdiseases
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Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases

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