Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics

Abstract This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects...

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Autores principales:	Min Jye Cho, Sung Ho Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bb8bf0942dd4243b06a1d8637b423d5
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spelling	oai:doaj.org-article:5bb8bf0942dd4243b06a1d8637b423d52021-12-02T17:04:34ZRelationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics10.1038/s41598-021-86439-02045-2322https://doaj.org/article/5bb8bf0942dd4243b06a1d8637b423d52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86439-0https://doaj.org/toc/2045-2322Abstract This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients.Min Jye ChoSung Ho JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Jye Cho Sung Ho Jang Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
description	Abstract This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients.
format	article
author	Min Jye Cho Sung Ho Jang
author_facet	Min Jye Cho Sung Ho Jang
author_sort	Min Jye Cho
title	Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_short	Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_full	Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_fullStr	Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_full_unstemmed	Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_sort	relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bb8bf0942dd4243b06a1d8637b423d5
work_keys_str_mv	AT minjyecho relationshipbetweenposttraumaticamnesiaandwhitematterintegrityintraumaticbraininjuryusingtractbasedspatialstatistics AT sunghojang relationshipbetweenposttraumaticamnesiaandwhitematterintegrityintraumaticbraininjuryusingtractbasedspatialstatistics
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Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics

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