Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles
Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or ‘know-how’. Additionally, standard protocols do not allow for scale up, and this is significantly hi...
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MDPI AG
2021
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oai:doaj.org-article:5bbb901408dc4078938d7dedd90f7c4d2021-11-25T18:31:19ZInvestigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles10.3390/nano111129762079-4991https://doaj.org/article/5bbb901408dc4078938d7dedd90f7c4d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2976https://doaj.org/toc/2079-4991Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or ‘know-how’. Additionally, standard protocols do not allow for scale up, and this is significantly hindering their future potential. In this study, we seek to determine whether microfluidics could be used as a new manufacturing process to reliably produce hybrid nanoparticles with the line of sight to their continuous manufacture and scaleup. Using a Precision Nano NanoAssemblr Benchtop<sup>®</sup> system, we were able to perform the intermediate coating steps required in order to construct hybrid nanoparticles around 60 nm in size with similar chemical and physical properties to those synthesised in the laboratory using standard processes, with Fe/Au ratios of 1:0.6 (standard) and 1:0.7 (microfluidics), indicating that the process was suitable for their manufacture with optimisation required in order to configure a continuous manufacturing plant.Adeolu OluwasanmiErnest ManAnthony CurtisHumphrey H. P. YiuYvonne PerrieClare HoskinsMDPI AGarticlehybrid nanoparticlemanufacturescale upmicrofluidicsnanotechnologyChemistryQD1-999ENNanomaterials, Vol 11, Iss 2976, p 2976 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
hybrid nanoparticle manufacture scale up microfluidics nanotechnology Chemistry QD1-999 |
| spellingShingle |
hybrid nanoparticle manufacture scale up microfluidics nanotechnology Chemistry QD1-999 Adeolu Oluwasanmi Ernest Man Anthony Curtis Humphrey H. P. Yiu Yvonne Perrie Clare Hoskins Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| description |
Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or ‘know-how’. Additionally, standard protocols do not allow for scale up, and this is significantly hindering their future potential. In this study, we seek to determine whether microfluidics could be used as a new manufacturing process to reliably produce hybrid nanoparticles with the line of sight to their continuous manufacture and scaleup. Using a Precision Nano NanoAssemblr Benchtop<sup>®</sup> system, we were able to perform the intermediate coating steps required in order to construct hybrid nanoparticles around 60 nm in size with similar chemical and physical properties to those synthesised in the laboratory using standard processes, with Fe/Au ratios of 1:0.6 (standard) and 1:0.7 (microfluidics), indicating that the process was suitable for their manufacture with optimisation required in order to configure a continuous manufacturing plant. |
| format |
article |
| author |
Adeolu Oluwasanmi Ernest Man Anthony Curtis Humphrey H. P. Yiu Yvonne Perrie Clare Hoskins |
| author_facet |
Adeolu Oluwasanmi Ernest Man Anthony Curtis Humphrey H. P. Yiu Yvonne Perrie Clare Hoskins |
| author_sort |
Adeolu Oluwasanmi |
| title |
Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| title_short |
Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| title_full |
Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| title_fullStr |
Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| title_full_unstemmed |
Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles |
| title_sort |
investigation into the use of microfluidics in the manufacture of metallic gold-coated iron oxide hybrid nanoparticles |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/5bbb901408dc4078938d7dedd90f7c4d |
| work_keys_str_mv |
AT adeoluoluwasanmi investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles AT ernestman investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles AT anthonycurtis investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles AT humphreyhpyiu investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles AT yvonneperrie investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles AT clarehoskins investigationintotheuseofmicrofluidicsinthemanufactureofmetallicgoldcoatedironoxidehybridnanoparticles |
| _version_ |
1718411018086907904 |