NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an endogenous inhibitor of PARP enzymes.

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Autores principales:	Chunjing Bian, Chao Zhang, Tao Luo, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong, Xiaochun Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5bbffa525898454999e7e01354382c95
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spelling	oai:doaj.org-article:5bbffa525898454999e7e01354382c952021-12-02T16:57:41ZNADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression10.1038/s41467-019-08530-52041-1723https://doaj.org/article/5bbffa525898454999e7e01354382c952019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08530-5https://doaj.org/toc/2041-1723Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an endogenous inhibitor of PARP enzymes.Chunjing BianChao ZhangTao LuoAditi VyasShih-Hsun ChenChao LiuMuzaffer Ahmad KassabYing YangMei KongXiaochun YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunjing Bian Chao Zhang Tao Luo Aditi Vyas Shih-Hsun Chen Chao Liu Muzaffer Ahmad Kassab Ying Yang Mei Kong Xiaochun Yu NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
description	Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an endogenous inhibitor of PARP enzymes.
format	article
author	Chunjing Bian Chao Zhang Tao Luo Aditi Vyas Shih-Hsun Chen Chao Liu Muzaffer Ahmad Kassab Ying Yang Mei Kong Xiaochun Yu
author_facet	Chunjing Bian Chao Zhang Tao Luo Aditi Vyas Shih-Hsun Chen Chao Liu Muzaffer Ahmad Kassab Ying Yang Mei Kong Xiaochun Yu
author_sort	Chunjing Bian
title	NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
title_short	NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
title_full	NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
title_fullStr	NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
title_full_unstemmed	NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
title_sort	nadp+ is an endogenous parp inhibitor in dna damage response and tumor suppression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5bbffa525898454999e7e01354382c95
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NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

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