A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YA...

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Autores principales: Ines Jeric, Gabriele Maurer, Anna Lina Cavallo, Josipa Raguz, Enrico Desideri, Bartosz Tarkowski, Matthias Parrini, Irmgard Fischer, Kurt Zatloukal, Manuela Baccarini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5bc4b495b6cf4f9894441a93a6563ceb
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spelling oai:doaj.org-article:5bc4b495b6cf4f9894441a93a6563ceb2021-12-02T17:31:18ZA cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis10.1038/ncomms137812041-1723https://doaj.org/article/5bc4b495b6cf4f9894441a93a6563ceb2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13781https://doaj.org/toc/2041-1723The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YAP1 regulation.Ines JericGabriele MaurerAnna Lina CavalloJosipa RaguzEnrico DesideriBartosz TarkowskiMatthias ParriniIrmgard FischerKurt ZatloukalManuela BaccariniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ines Jeric
Gabriele Maurer
Anna Lina Cavallo
Josipa Raguz
Enrico Desideri
Bartosz Tarkowski
Matthias Parrini
Irmgard Fischer
Kurt Zatloukal
Manuela Baccarini
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
description The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YAP1 regulation.
format article
author Ines Jeric
Gabriele Maurer
Anna Lina Cavallo
Josipa Raguz
Enrico Desideri
Bartosz Tarkowski
Matthias Parrini
Irmgard Fischer
Kurt Zatloukal
Manuela Baccarini
author_facet Ines Jeric
Gabriele Maurer
Anna Lina Cavallo
Josipa Raguz
Enrico Desideri
Bartosz Tarkowski
Matthias Parrini
Irmgard Fischer
Kurt Zatloukal
Manuela Baccarini
author_sort Ines Jeric
title A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
title_short A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
title_full A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
title_fullStr A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
title_full_unstemmed A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
title_sort cell-autonomous tumour suppressor role of raf1 in hepatocarcinogenesis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/5bc4b495b6cf4f9894441a93a6563ceb
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