Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes

Abstract Preterm birth (PTB) is a major cause of neonatal mortality and health complications in infants. Elucidation of its genetic underpinnings can lead to improved understanding of the biological mechanisms and boost the development of methods to predict PTB. Although recent genome-based studies...

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Autores principales:	Esha Bhattacharjee, Arindam Maitra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/5bc804c02e3246c7acde09dfd1e727be
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spelling	oai:doaj.org-article:5bc804c02e3246c7acde09dfd1e727be2021-12-02T15:03:08ZSpontaneous preterm birth: the underpinnings in the maternal and fetal genomes10.1038/s41525-021-00209-52056-7944https://doaj.org/article/5bc804c02e3246c7acde09dfd1e727be2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00209-5https://doaj.org/toc/2056-7944Abstract Preterm birth (PTB) is a major cause of neonatal mortality and health complications in infants. Elucidation of its genetic underpinnings can lead to improved understanding of the biological mechanisms and boost the development of methods to predict PTB. Although recent genome-based studies of both mother and fetus have identified several genetic loci which might be implicated in PTB, these results suffer from a lack of consistency across multiple studies and populations. Moreover, results of functional validation of most of these findings are unavailable. Since medically indicated preterm deliveries have well-known heterogeneous causes, we have reviewed only those studies which investigated spontaneous preterm birth (sPTB) and have attempted to suggest probable biological mechanisms by which the implicated genetic factors might result in sPTB. We expect our review to provide a panoramic view of the genetics of sPTB.Esha BhattacharjeeArindam MaitraNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Esha Bhattacharjee Arindam Maitra Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
description	Abstract Preterm birth (PTB) is a major cause of neonatal mortality and health complications in infants. Elucidation of its genetic underpinnings can lead to improved understanding of the biological mechanisms and boost the development of methods to predict PTB. Although recent genome-based studies of both mother and fetus have identified several genetic loci which might be implicated in PTB, these results suffer from a lack of consistency across multiple studies and populations. Moreover, results of functional validation of most of these findings are unavailable. Since medically indicated preterm deliveries have well-known heterogeneous causes, we have reviewed only those studies which investigated spontaneous preterm birth (sPTB) and have attempted to suggest probable biological mechanisms by which the implicated genetic factors might result in sPTB. We expect our review to provide a panoramic view of the genetics of sPTB.
format	article
author	Esha Bhattacharjee Arindam Maitra
author_facet	Esha Bhattacharjee Arindam Maitra
author_sort	Esha Bhattacharjee
title	Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
title_short	Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
title_full	Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
title_fullStr	Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
title_full_unstemmed	Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
title_sort	spontaneous preterm birth: the underpinnings in the maternal and fetal genomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bc804c02e3246c7acde09dfd1e727be
work_keys_str_mv	AT eshabhattacharjee spontaneouspretermbirththeunderpinningsinthematernalandfetalgenomes AT arindammaitra spontaneouspretermbirththeunderpinningsinthematernalandfetalgenomes
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Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes

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