Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personaliz...

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Autores principales:	Alexander A. Strait, Rachel A. Woolaver, Spencer C. Hall, Christian D. Young, Sana D. Karam, Antonio Jimeno, Yan Lan, David Raben, Jing H. Wang, Xiao-Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5bc8510595ab4074a4ee88ee8f72c43b
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spelling	oai:doaj.org-article:5bc8510595ab4074a4ee88ee8f72c43b2021-12-02T15:09:14ZDistinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma10.1038/s42003-021-02522-22399-3642https://doaj.org/article/5bc8510595ab4074a4ee88ee8f72c43b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02522-2https://doaj.org/toc/2399-3642Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personalized SCC immunotherapy.Alexander A. StraitRachel A. WoolaverSpencer C. HallChristian D. YoungSana D. KaramAntonio JimenoYan LanDavid RabenJing H. WangXiao-Jing WangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
description	Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personalized SCC immunotherapy.
format	article
author	Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang
author_facet	Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang
author_sort	Alexander A. Strait
title	Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
title_short	Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
title_full	Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
title_fullStr	Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
title_full_unstemmed	Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
title_sort	distinct immune microenvironment profiles of therapeutic responders emerge in combined tgfβ/pd-l1 blockade-treated squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bc8510595ab4074a4ee88ee8f72c43b
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Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

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