Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus

The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identificati...

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Autores principales:	A. Jan, H. Jan, Z. Ullah
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	transcription factor-7– like 2 (tcf7l2) type 2 diabetes wnt signaling pathways genome wise association studies (gwas) Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5bcace4affa548c5aa07284a06b6e26a
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spelling	oai:doaj.org-article:5bcace4affa548c5aa07284a06b6e26a2021-11-14T09:00:23ZTranscription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus2072-03512072-037810.14341/DM12313https://doaj.org/article/5bcace4affa548c5aa07284a06b6e26a2021-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12313https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identification of transcription factor 7-like 2 (TCF7L2) gene an important marker in predisposition of type 2 diabetes in almost all ethnic population. Recent genetic research identifies numerous novel type 2 diabetes susceptible genes among these genes TCF7L2 is considered as gang head and emerged as the most promising types 2 diabetes causing gene. Risk variants in TCF7L2 effects pancreatic beta cell development and insulin secretion by influencing Wnt Signaling pathway. Genetic variants in TCF7L2 confer risk for type 2 diabetes by altering expression of transcription factor (which has key role in blood glucose regulation) in pancreas. The purpose of this paper is to evaluate type 2 diabetes susceptible gene the TCF7L2 and to present a comprehensive review of studies carried out worldwide in different ethnic population on association of TCF7L2 polymorphism with type 2 diabetes.A. JanH. JanZ. UllahEndocrinology Research Centrearticletranscription factor-7– like 2 (tcf7l2)type 2 diabeteswnt signaling pathwaysgenome wise association studies (gwas)Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 4, Pp 371-376 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	transcription factor-7– like 2 (tcf7l2) type 2 diabetes wnt signaling pathways genome wise association studies (gwas) Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	transcription factor-7– like 2 (tcf7l2) type 2 diabetes wnt signaling pathways genome wise association studies (gwas) Nutritional diseases. Deficiency diseases RC620-627 A. Jan H. Jan Z. Ullah Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
description	The genetics of Type 2 diabetes a complex metabolic disorder, characterized by decreased insulin secretion and insulin resistance resulting in impaired blood glucose homeostasis remains enigma for geneticists. In 2006 an important step while finding genetic causes of diabetes type 2 was identification of transcription factor 7-like 2 (TCF7L2) gene an important marker in predisposition of type 2 diabetes in almost all ethnic population. Recent genetic research identifies numerous novel type 2 diabetes susceptible genes among these genes TCF7L2 is considered as gang head and emerged as the most promising types 2 diabetes causing gene. Risk variants in TCF7L2 effects pancreatic beta cell development and insulin secretion by influencing Wnt Signaling pathway. Genetic variants in TCF7L2 confer risk for type 2 diabetes by altering expression of transcription factor (which has key role in blood glucose regulation) in pancreas. The purpose of this paper is to evaluate type 2 diabetes susceptible gene the TCF7L2 and to present a comprehensive review of studies carried out worldwide in different ethnic population on association of TCF7L2 polymorphism with type 2 diabetes.
format	article
author	A. Jan H. Jan Z. Ullah
author_facet	A. Jan H. Jan Z. Ullah
author_sort	A. Jan
title	Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
title_short	Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
title_full	Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
title_fullStr	Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
title_full_unstemmed	Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
title_sort	transcription factor 7-like 2 (tcf7l2): a culprit gene in type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/5bcace4affa548c5aa07284a06b6e26a
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Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus

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