The use of pulse pressure variation for predicting impairment of microcirculatory blood flow
Abstract Dynamic parameters of preload have been widely recommended to guide fluid therapy based on the principle of fluid responsiveness and with regard to cardiac output. An equally important aspect is however to also avoid volume-overload. This accounts particularly when capillary leakage is pres...
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Nature Portfolio
2021
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oai:doaj.org-article:5bcb78668b194fa38b398e818d18595d2021-12-02T17:39:31ZThe use of pulse pressure variation for predicting impairment of microcirculatory blood flow10.1038/s41598-021-88458-32045-2322https://doaj.org/article/5bcb78668b194fa38b398e818d18595d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88458-3https://doaj.org/toc/2045-2322Abstract Dynamic parameters of preload have been widely recommended to guide fluid therapy based on the principle of fluid responsiveness and with regard to cardiac output. An equally important aspect is however to also avoid volume-overload. This accounts particularly when capillary leakage is present and volume-overload will promote impairment of microcirculatory blood flow. The aim of this study was to evaluate, whether an impairment of intestinal microcirculation caused by volume-load potentially can be predicted using pulse pressure variation in an experimental model of ischemia/reperfusion injury. The study was designed as a prospective explorative large animal pilot study. The study was performed in 8 anesthetized domestic pigs (German landrace). Ischemia/reperfusion was induced during aortic surgery. 6 h after ischemia/reperfusion-injury measurements were performed during 4 consecutive volume-loading-steps, each consisting of 6 ml kg−1 bodyweight−1. Mean microcirculatory blood flow (mean Flux) of the ileum was measured using direct laser-speckle-contrast-imaging. Receiver operating characteristic analysis was performed to determine the ability of pulse pressure variation to predict a decrease in microcirculation. A reduction of ≥ 10% mean Flux was considered a relevant decrease. After ischemia–reperfusion, volume-loading-steps led to a significant increase of cardiac output as well as mean arterial pressure, while pulse pressure variation and mean Flux were significantly reduced (Pairwise comparison ischemia/reperfusion-injury vs. volume loading step no. 4): cardiac output (l min−1) 1.68 (1.02–2.35) versus 2.84 (2.15–3.53), p = 0.002, mean arterial pressure (mmHg) 29.89 (21.65–38.12) versus 52.34 (43.55–61.14), p < 0.001, pulse pressure variation (%) 24.84 (17.45–32.22) versus 9.59 (1.68–17.49), p = 0.004, mean Flux (p.u.) 414.95 (295.18–534.72) versus 327.21 (206.95–447.48), p = 0.006. Receiver operating characteristic analysis revealed an area under the curve of 0.88 (CI 95% 0.73–1.00; p value < 0.001) for pulse pressure variation for predicting a decrease of microcirculatory blood flow. The results of our study show that pulse pressure variation does have the potential to predict decreases of intestinal microcirculatory blood flow due to volume-load after ischemia/reperfusion-injury. This should encourage further translational research and might help to prevent microcirculatory impairment due to excessive fluid resuscitation and to guide fluid therapy in the future.Christoph R. BehemMichael F. GraesslerTill FriedheimRahel KluttigHans O. PinnschmidtAnna DupréeE. Sebastian DebusDaniel A. ReuterSabine H. WipperConstantin J. C. TrepteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Christoph R. Behem Michael F. Graessler Till Friedheim Rahel Kluttig Hans O. Pinnschmidt Anna Duprée E. Sebastian Debus Daniel A. Reuter Sabine H. Wipper Constantin J. C. Trepte The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| description |
Abstract Dynamic parameters of preload have been widely recommended to guide fluid therapy based on the principle of fluid responsiveness and with regard to cardiac output. An equally important aspect is however to also avoid volume-overload. This accounts particularly when capillary leakage is present and volume-overload will promote impairment of microcirculatory blood flow. The aim of this study was to evaluate, whether an impairment of intestinal microcirculation caused by volume-load potentially can be predicted using pulse pressure variation in an experimental model of ischemia/reperfusion injury. The study was designed as a prospective explorative large animal pilot study. The study was performed in 8 anesthetized domestic pigs (German landrace). Ischemia/reperfusion was induced during aortic surgery. 6 h after ischemia/reperfusion-injury measurements were performed during 4 consecutive volume-loading-steps, each consisting of 6 ml kg−1 bodyweight−1. Mean microcirculatory blood flow (mean Flux) of the ileum was measured using direct laser-speckle-contrast-imaging. Receiver operating characteristic analysis was performed to determine the ability of pulse pressure variation to predict a decrease in microcirculation. A reduction of ≥ 10% mean Flux was considered a relevant decrease. After ischemia–reperfusion, volume-loading-steps led to a significant increase of cardiac output as well as mean arterial pressure, while pulse pressure variation and mean Flux were significantly reduced (Pairwise comparison ischemia/reperfusion-injury vs. volume loading step no. 4): cardiac output (l min−1) 1.68 (1.02–2.35) versus 2.84 (2.15–3.53), p = 0.002, mean arterial pressure (mmHg) 29.89 (21.65–38.12) versus 52.34 (43.55–61.14), p < 0.001, pulse pressure variation (%) 24.84 (17.45–32.22) versus 9.59 (1.68–17.49), p = 0.004, mean Flux (p.u.) 414.95 (295.18–534.72) versus 327.21 (206.95–447.48), p = 0.006. Receiver operating characteristic analysis revealed an area under the curve of 0.88 (CI 95% 0.73–1.00; p value < 0.001) for pulse pressure variation for predicting a decrease of microcirculatory blood flow. The results of our study show that pulse pressure variation does have the potential to predict decreases of intestinal microcirculatory blood flow due to volume-load after ischemia/reperfusion-injury. This should encourage further translational research and might help to prevent microcirculatory impairment due to excessive fluid resuscitation and to guide fluid therapy in the future. |
| format |
article |
| author |
Christoph R. Behem Michael F. Graessler Till Friedheim Rahel Kluttig Hans O. Pinnschmidt Anna Duprée E. Sebastian Debus Daniel A. Reuter Sabine H. Wipper Constantin J. C. Trepte |
| author_facet |
Christoph R. Behem Michael F. Graessler Till Friedheim Rahel Kluttig Hans O. Pinnschmidt Anna Duprée E. Sebastian Debus Daniel A. Reuter Sabine H. Wipper Constantin J. C. Trepte |
| author_sort |
Christoph R. Behem |
| title |
The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| title_short |
The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| title_full |
The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| title_fullStr |
The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| title_full_unstemmed |
The use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| title_sort |
use of pulse pressure variation for predicting impairment of microcirculatory blood flow |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5bcb78668b194fa38b398e818d18595d |
| work_keys_str_mv |
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