A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells

Geeta Shroff Department of Stem Cell Therapy, Nutech Mediworld, New Delhi, India Abstract: Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its managemen...

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Autor principal:	Shroff G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Multiple sclerosis (MS) Stem cells Human embryonic stem cells (hESC) Remyelination Axonal loss Cytology QH573-671
Acceso en línea:	https://doaj.org/article/5bd2c5c190e44d3aabd9ce6b0b5bb121
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spelling	oai:doaj.org-article:5bd2c5c190e44d3aabd9ce6b0b5bb1212021-12-02T06:18:57ZA review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells1178-6957https://doaj.org/article/5bd2c5c190e44d3aabd9ce6b0b5bb1212018-02-01T00:00:00Zhttps://www.dovepress.com/a-review-on-stem-cell-therapy-for-multiple-sclerosis-special-focus-on--peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Geeta Shroff Department of Stem Cell Therapy, Nutech Mediworld, New Delhi, India Abstract: Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury. Human embryonic stem cell (hESC) transplantation is one of the promising cell therapies; hESCs play an important role in remyelination and help in preventing demylenation of the axons. In this study, an overview of the current knowledge about the unique properties of hESC and their comparison with other cell therapies has been presented for the treatment of patients with MS. Keywords: multiple sclerosis, stem cells, human embryonic stem cells, remyelination, axonal loss, neurological disorderShroff GDove Medical PressarticleMultiple sclerosis (MS)Stem cellsHuman embryonic stem cells (hESC)RemyelinationAxonal lossCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 11, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple sclerosis (MS) Stem cells Human embryonic stem cells (hESC) Remyelination Axonal loss Cytology QH573-671
spellingShingle	Multiple sclerosis (MS) Stem cells Human embryonic stem cells (hESC) Remyelination Axonal loss Cytology QH573-671 Shroff G A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
description	Geeta Shroff Department of Stem Cell Therapy, Nutech Mediworld, New Delhi, India Abstract: Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury. Human embryonic stem cell (hESC) transplantation is one of the promising cell therapies; hESCs play an important role in remyelination and help in preventing demylenation of the axons. In this study, an overview of the current knowledge about the unique properties of hESC and their comparison with other cell therapies has been presented for the treatment of patients with MS. Keywords: multiple sclerosis, stem cells, human embryonic stem cells, remyelination, axonal loss, neurological disorder
format	article
author	Shroff G
author_facet	Shroff G
author_sort	Shroff G
title	A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
title_short	A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
title_full	A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
title_fullStr	A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
title_full_unstemmed	A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
title_sort	review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5bd2c5c190e44d3aabd9ce6b0b5bb121
work_keys_str_mv	AT shroffg areviewonstemcelltherapyformultiplesclerosisspecialfocusonhumanembryonicstemcells AT shroffg reviewonstemcelltherapyformultiplesclerosisspecialfocusonhumanembryonicstemcells
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A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells

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