Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.

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Detalles Bibliográficos
Autores principales: Q. Heydt, C. Xintaropoulou, A. Clear, M. Austin, I. Pislariu, F. Miraki-Moud, P. Cutillas, K. Korfi, M. Calaminici, W. Cawthorn, K. Suchacki, A. Nagano, J. G. Gribben, M. Smith, J. D. Cavenagh, H. Oakervee, A. Castleton, D. Taussig, B. Peck, A. Wilczynska, L. McNaughton, D. Bonnet, F. Mardakheh, B. Patel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5bd437ead45f4de29da3fc82c6989399
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Sumario:How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.

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