Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence
How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5bd437ead45f4de29da3fc82c6989399 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5bd437ead45f4de29da3fc82c6989399 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5bd437ead45f4de29da3fc82c69893992021-12-02T15:31:28ZAdipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence10.1038/s41467-021-25540-42041-1723https://doaj.org/article/5bd437ead45f4de29da3fc82c69893992021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25540-4https://doaj.org/toc/2041-1723How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.Q. HeydtC. XintaropoulouA. ClearM. AustinI. PislariuF. Miraki-MoudP. CutillasK. KorfiM. CalaminiciW. CawthornK. SuchackiA. NaganoJ. G. GribbenM. SmithJ. D. CavenaghH. OakerveeA. CastletonD. TaussigB. PeckA. WilczynskaL. McNaughtonD. BonnetF. MardakhehB. PatelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Q. Heydt C. Xintaropoulou A. Clear M. Austin I. Pislariu F. Miraki-Moud P. Cutillas K. Korfi M. Calaminici W. Cawthorn K. Suchacki A. Nagano J. G. Gribben M. Smith J. D. Cavenagh H. Oakervee A. Castleton D. Taussig B. Peck A. Wilczynska L. McNaughton D. Bonnet F. Mardakheh B. Patel Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| description |
How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome. |
| format |
article |
| author |
Q. Heydt C. Xintaropoulou A. Clear M. Austin I. Pislariu F. Miraki-Moud P. Cutillas K. Korfi M. Calaminici W. Cawthorn K. Suchacki A. Nagano J. G. Gribben M. Smith J. D. Cavenagh H. Oakervee A. Castleton D. Taussig B. Peck A. Wilczynska L. McNaughton D. Bonnet F. Mardakheh B. Patel |
| author_facet |
Q. Heydt C. Xintaropoulou A. Clear M. Austin I. Pislariu F. Miraki-Moud P. Cutillas K. Korfi M. Calaminici W. Cawthorn K. Suchacki A. Nagano J. G. Gribben M. Smith J. D. Cavenagh H. Oakervee A. Castleton D. Taussig B. Peck A. Wilczynska L. McNaughton D. Bonnet F. Mardakheh B. Patel |
| author_sort |
Q. Heydt |
| title |
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| title_short |
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| title_full |
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| title_fullStr |
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| title_full_unstemmed |
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| title_sort |
adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5bd437ead45f4de29da3fc82c6989399 |
| work_keys_str_mv |
AT qheydt adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT cxintaropoulou adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT aclear adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT maustin adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT ipislariu adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT fmirakimoud adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT pcutillas adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT kkorfi adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT mcalaminici adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT wcawthorn adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT ksuchacki adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT anagano adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT jggribben adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT msmith adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT jdcavenagh adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT hoakervee adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT acastleton adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT dtaussig adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT bpeck adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT awilczynska adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT lmcnaughton adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT dbonnet adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT fmardakheh adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence AT bpatel adipocytesdisruptthetranslationalprogrammeofacutelymphoblasticleukaemiatofavourtumoursurvivalandpersistence |
| _version_ |
1718387143561183232 |