The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma

This study was designed to evaluate the effectiveness of curcumin supplement as antioxidant and anti-inflammatory in patients with chronic bronchial asthma. Forty patients diagnosed with chronic bronchial asthma were enrolled in this study and allocated into group (1) patients assigned to receive...

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Autores principales:	Sura Abbas Khdair, Manal Khalid Abdulridha, Mostafa Abdalfatah Shafek
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	chronic bronchial asthma, pulmonary function, curcumin supplement, interleukin-6 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5bd4fa43a17a46bcb3713b0b6b0437a5
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spelling	oai:doaj.org-article:5bd4fa43a17a46bcb3713b0b6b0437a52021-11-15T06:08:47ZThe Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma2338-94272338-948610.22146/ijp.1136https://doaj.org/article/5bd4fa43a17a46bcb3713b0b6b0437a52021-04-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1136https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486This study was designed to evaluate the effectiveness of curcumin supplement as antioxidant and anti-inflammatory in patients with chronic bronchial asthma. Forty patients diagnosed with chronic bronchial asthma were enrolled in this study and allocated into group (1) patients assigned to receive conventional therapy of asthma, and group (2) patient assigned to receive conventional therapy of asthma combined with 750 mg curcumin supplement twice daily for two months. Pulmonary function test, asthma control test, serum interleukin-6 and serum extracellular super oxide dismutase 3 were measured before and after two months in both study groups. After two months, the mean values of pulmonary function test (spirometry) and asthma control score showed significant increase compared to pre-treatment values in group 2 patients (P<0.01). Moreover, there was marked decrease in the level of interleukin-6 in group 2 patients after two months (p< 0.05) compared to the increased in group 1 patients. The mean level of super oxide dismutase 3 didn’t show any increase in both study groups after treatment. Curcumin supplement produced improvement in pulmonary function of patients with chronic bronchial asthma along with the reduction in inflammatory status. No change in endogenous oxidative status after curcumin supplementation.Sura Abbas KhdairManal Khalid AbdulridhaMostafa Abdalfatah ShafekUniversitas Gadjah Madaarticlechronic bronchial asthma, pulmonary function, curcumin supplement, interleukin-6Pharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 232-240 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic bronchial asthma, pulmonary function, curcumin supplement, interleukin-6 Pharmacy and materia medica RS1-441
spellingShingle	chronic bronchial asthma, pulmonary function, curcumin supplement, interleukin-6 Pharmacy and materia medica RS1-441 Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdalfatah Shafek The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
description	This study was designed to evaluate the effectiveness of curcumin supplement as antioxidant and anti-inflammatory in patients with chronic bronchial asthma. Forty patients diagnosed with chronic bronchial asthma were enrolled in this study and allocated into group (1) patients assigned to receive conventional therapy of asthma, and group (2) patient assigned to receive conventional therapy of asthma combined with 750 mg curcumin supplement twice daily for two months. Pulmonary function test, asthma control test, serum interleukin-6 and serum extracellular super oxide dismutase 3 were measured before and after two months in both study groups. After two months, the mean values of pulmonary function test (spirometry) and asthma control score showed significant increase compared to pre-treatment values in group 2 patients (P<0.01). Moreover, there was marked decrease in the level of interleukin-6 in group 2 patients after two months (p< 0.05) compared to the increased in group 1 patients. The mean level of super oxide dismutase 3 didn’t show any increase in both study groups after treatment. Curcumin supplement produced improvement in pulmonary function of patients with chronic bronchial asthma along with the reduction in inflammatory status. No change in endogenous oxidative status after curcumin supplementation.
format	article
author	Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdalfatah Shafek
author_facet	Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdalfatah Shafek
author_sort	Sura Abbas Khdair
title	The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
title_short	The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
title_full	The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
title_fullStr	The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
title_full_unstemmed	The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma
title_sort	effect of curcumin adjuvant therapy on pulmonary function and levels of interleukin-6 (il-6) and superoxide dismutase-3 (ec-sod3) in patients with chronic bronchial asthma
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/5bd4fa43a17a46bcb3713b0b6b0437a5
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The Effect of Curcumin Adjuvant Therapy on Pulmonary Function and Levels of Interleukin-6 (IL-6) and Superoxide Dismutase-3 (EC-SOD3) in Patients with Chronic Bronchial Asthma

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