Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.

To contribute to a further insight into heterosis we applied an integrative analysis to a systems biological network approach and a quantitative genetics analysis towards biomass heterosis in early Arabidopsis thaliana development. The study was performed on the parental accessions C24 and Col-0 and...

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Autores principales:	Sandra Andorf, Rhonda C Meyer, Joachim Selbig, Thomas Altmann, Dirk Repsilber
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bd60eaf7877480d9a9dc135bef1dd78
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spelling	oai:doaj.org-article:5bd60eaf7877480d9a9dc135bef1dd782021-11-18T08:08:26ZIntegration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.1932-620310.1371/journal.pone.0049951https://doaj.org/article/5bd60eaf7877480d9a9dc135bef1dd782012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166802/?tool=EBIhttps://doaj.org/toc/1932-6203To contribute to a further insight into heterosis we applied an integrative analysis to a systems biological network approach and a quantitative genetics analysis towards biomass heterosis in early Arabidopsis thaliana development. The study was performed on the parental accessions C24 and Col-0 and the reciprocal crosses. In an over-representation analysis it was tested if the overlap between the resulting gene lists of the two approaches is significantly larger than expected by chance. Top ranked genes in the results list of the systems biological analysis were significantly over-represented in the heterotic QTL candidate regions for either hybrid as well as regarding mid-parent and best-parent heterosis. This suggests that not only a few but rather several genes that influence biomass heterosis are located within each heterotic QTL region. Furthermore, the overlapping resulting genes of the two integrated approaches were particularly enriched in biomass related pathways. A chromosome-wise over-representation analysis gave rise to the hypothesis that chromosomes number 2 and 4 probably carry a majority of the genes involved in biomass heterosis in the early development of Arabidopsis thaliana.Sandra AndorfRhonda C MeyerJoachim SelbigThomas AltmannDirk RepsilberPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49951 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Andorf Rhonda C Meyer Joachim Selbig Thomas Altmann Dirk Repsilber Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
description	To contribute to a further insight into heterosis we applied an integrative analysis to a systems biological network approach and a quantitative genetics analysis towards biomass heterosis in early Arabidopsis thaliana development. The study was performed on the parental accessions C24 and Col-0 and the reciprocal crosses. In an over-representation analysis it was tested if the overlap between the resulting gene lists of the two approaches is significantly larger than expected by chance. Top ranked genes in the results list of the systems biological analysis were significantly over-represented in the heterotic QTL candidate regions for either hybrid as well as regarding mid-parent and best-parent heterosis. This suggests that not only a few but rather several genes that influence biomass heterosis are located within each heterotic QTL region. Furthermore, the overlapping resulting genes of the two integrated approaches were particularly enriched in biomass related pathways. A chromosome-wise over-representation analysis gave rise to the hypothesis that chromosomes number 2 and 4 probably carry a majority of the genes involved in biomass heterosis in the early development of Arabidopsis thaliana.
format	article
author	Sandra Andorf Rhonda C Meyer Joachim Selbig Thomas Altmann Dirk Repsilber
author_facet	Sandra Andorf Rhonda C Meyer Joachim Selbig Thomas Altmann Dirk Repsilber
author_sort	Sandra Andorf
title	Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
title_short	Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
title_full	Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
title_fullStr	Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
title_full_unstemmed	Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.
title_sort	integration of a systems biological network analysis and qtl results for biomass heterosis in arabidopsis thaliana.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5bd60eaf7877480d9a9dc135bef1dd78
work_keys_str_mv	AT sandraandorf integrationofasystemsbiologicalnetworkanalysisandqtlresultsforbiomassheterosisinarabidopsisthaliana AT rhondacmeyer integrationofasystemsbiologicalnetworkanalysisandqtlresultsforbiomassheterosisinarabidopsisthaliana AT joachimselbig integrationofasystemsbiologicalnetworkanalysisandqtlresultsforbiomassheterosisinarabidopsisthaliana AT thomasaltmann integrationofasystemsbiologicalnetworkanalysisandqtlresultsforbiomassheterosisinarabidopsisthaliana AT dirkrepsilber integrationofasystemsbiologicalnetworkanalysisandqtlresultsforbiomassheterosisinarabidopsisthaliana
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Integration of a systems biological network analysis and QTL results for biomass heterosis in Arabidopsis thaliana.

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