Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies
Peifu Wang, Jilai Li, Shi Qiu, Honfeng Wen, Jichen DuDepartment of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, People’s Republic of ChinaBackground and purpose: Published data on the relationship of hormone replacement therapy (HRT) with Pa...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5bd63efc854145f5822a97fbec8d04ea |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5bd63efc854145f5822a97fbec8d04ea |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5bd63efc854145f5822a97fbec8d04ea2021-12-02T04:22:44ZHormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies1178-2021https://doaj.org/article/5bd63efc854145f5822a97fbec8d04ea2014-12-01T00:00:00Zhttp://www.dovepress.com/hormone-replacement-therapy-and-parkinsonrsquos-disease-risk-in-women--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Peifu Wang, Jilai Li, Shi Qiu, Honfeng Wen, Jichen DuDepartment of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, People’s Republic of ChinaBackground and purpose: Published data on the relationship of hormone replacement therapy (HRT) with Parkinson’s disease (PD) were inconclusive. Thus, a systematic meta-analysis of observational studies was performed to clarify this topic.Methods: The databases of PubMed and EMBASE were searched for case–control or cohort studies published up till June 2, 2014. Meta-analysis of the relative risks (RRs) with 95% confidence intervals (CIs) was estimated using random-effects models.Results: A final total of ten case–control and four cohort studies were included in our meta-analysis. The overall combined RR of PD for ever users versus never users of HRT was 1.00 (95% CI: 0.84–1.20). Limited to those subjects who only use estrogen, a similar trend was detected (RR: 0.95, 95% CI: 0.69–1.30). In the subgroup analysis by study design, no significant association was observed in case–control studies (RR: 0.79, 95% CI: 0.62–1.02), whereas a positive association was found in cohort studies (RR: 1.24, 95% CI: 1.10–1.40). In further analysis according to study quality, an inverse association was found in the low-quality group (RR: 0.58, 95% CI: 0.40–0.82), whereas a positive association was found in the high-quality group (RR: 1.16, 95% CI: 1.02–1.31).Conclusion: In summary, our results of meta-analysis do not support a protective role of HRT in female PD development.Keywords: Parkinson’s disease, hormone replacement therapy, hormone meta-analysisWang PLi JQiu SWen HDu JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 59-66 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang P Li J Qiu S Wen H Du J Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| description |
Peifu Wang, Jilai Li, Shi Qiu, Honfeng Wen, Jichen DuDepartment of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, People’s Republic of ChinaBackground and purpose: Published data on the relationship of hormone replacement therapy (HRT) with Parkinson’s disease (PD) were inconclusive. Thus, a systematic meta-analysis of observational studies was performed to clarify this topic.Methods: The databases of PubMed and EMBASE were searched for case–control or cohort studies published up till June 2, 2014. Meta-analysis of the relative risks (RRs) with 95% confidence intervals (CIs) was estimated using random-effects models.Results: A final total of ten case–control and four cohort studies were included in our meta-analysis. The overall combined RR of PD for ever users versus never users of HRT was 1.00 (95% CI: 0.84–1.20). Limited to those subjects who only use estrogen, a similar trend was detected (RR: 0.95, 95% CI: 0.69–1.30). In the subgroup analysis by study design, no significant association was observed in case–control studies (RR: 0.79, 95% CI: 0.62–1.02), whereas a positive association was found in cohort studies (RR: 1.24, 95% CI: 1.10–1.40). In further analysis according to study quality, an inverse association was found in the low-quality group (RR: 0.58, 95% CI: 0.40–0.82), whereas a positive association was found in the high-quality group (RR: 1.16, 95% CI: 1.02–1.31).Conclusion: In summary, our results of meta-analysis do not support a protective role of HRT in female PD development.Keywords: Parkinson’s disease, hormone replacement therapy, hormone meta-analysis |
| format |
article |
| author |
Wang P Li J Qiu S Wen H Du J |
| author_facet |
Wang P Li J Qiu S Wen H Du J |
| author_sort |
Wang P |
| title |
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| title_short |
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| title_full |
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| title_fullStr |
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| title_full_unstemmed |
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| title_sort |
hormone replacement therapy and parkinson’s disease risk in women: a meta-analysis of 14 observational studies |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/5bd63efc854145f5822a97fbec8d04ea |
| work_keys_str_mv |
AT wangp hormonereplacementtherapyandparkinsonrsquosdiseaseriskinwomenametaanalysisof14observationalstudies AT lij hormonereplacementtherapyandparkinsonrsquosdiseaseriskinwomenametaanalysisof14observationalstudies AT qius hormonereplacementtherapyandparkinsonrsquosdiseaseriskinwomenametaanalysisof14observationalstudies AT wenh hormonereplacementtherapyandparkinsonrsquosdiseaseriskinwomenametaanalysisof14observationalstudies AT duj hormonereplacementtherapyandparkinsonrsquosdiseaseriskinwomenametaanalysisof14observationalstudies |
| _version_ |
1718401246353686528 |