The association between maternal cytomegalovirus urinary excretion and congenital infection rate

Abstract Background In utero Cytomegalovirus (CMV) vertical transmission occurs predominantly during primary maternal infection. There are no known non-invasive methods for diagnosis of fetal infection before delivery, however some risk factors have been suggested. We aimed to evaluate the associati...

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Autores principales:	Rita Zlatkin, Efraim Bilavsky, Joseph Pardo, Lina Salman, Ron Bardin, Eran Hadar, Anat Shmueli
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	CMV Cytomegalovirus Congenital infection Maternal infection Urinary excretion Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/5bd687c3f37240109c317bee28db260b
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spelling	oai:doaj.org-article:5bd687c3f37240109c317bee28db260b2021-11-08T11:04:19ZThe association between maternal cytomegalovirus urinary excretion and congenital infection rate10.1186/s12884-021-04194-61471-2393https://doaj.org/article/5bd687c3f37240109c317bee28db260b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04194-6https://doaj.org/toc/1471-2393Abstract Background In utero Cytomegalovirus (CMV) vertical transmission occurs predominantly during primary maternal infection. There are no known non-invasive methods for diagnosis of fetal infection before delivery, however some risk factors have been suggested. We aimed to evaluate the association between maternal CMV urinary excretion and congenital CMV infection. Methods A retrospective cohort study of all women who were diagnosed with primary CMV infection during pregnancy in a single university affiliated tertiary medical center, between 2012 and 2016. We examined congenital CMV infection and disease rates among infants born to women with and without CMV urinary excretion. Results Overall, 126 women were included, 77 in the positive urinary excretion group, and 49 in the negative urinary excretion group. There was no difference in maternal symptoms between the groups. We found no difference in congenital CMV infection and disease rates between infants born to women with and without urinary excretion of CMV (congenital infection rate 37.1% vs. 24.4%, p = 0.209, congenital disease rate of 18.2% vs. 22.4%, p = 0.648). Women with positive urinary CMV excretion had lower IgG avidity values (36.7% vs 54.6%, p = 0.007), with no additional difference in serology pattern. Compared to asymptomatic women, those with CMV related symptoms did not have significantly higher rates of urinary excretion of CMV (70% vs. 60.5%, p = 0.38) or congenital infection rates (40.7% vs. 31.2%, p = 0.48). Conclusion Among infants of women with primary CMV infection in pregnancy, we did not find an association between urinary excretion of CMV and congenital CMV infection.Rita ZlatkinEfraim BilavskyJoseph PardoLina SalmanRon BardinEran HadarAnat ShmueliBMCarticleCMVCytomegalovirusCongenital infectionMaternal infectionUrinary excretionGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CMV Cytomegalovirus Congenital infection Maternal infection Urinary excretion Gynecology and obstetrics RG1-991
spellingShingle	CMV Cytomegalovirus Congenital infection Maternal infection Urinary excretion Gynecology and obstetrics RG1-991 Rita Zlatkin Efraim Bilavsky Joseph Pardo Lina Salman Ron Bardin Eran Hadar Anat Shmueli The association between maternal cytomegalovirus urinary excretion and congenital infection rate
description	Abstract Background In utero Cytomegalovirus (CMV) vertical transmission occurs predominantly during primary maternal infection. There are no known non-invasive methods for diagnosis of fetal infection before delivery, however some risk factors have been suggested. We aimed to evaluate the association between maternal CMV urinary excretion and congenital CMV infection. Methods A retrospective cohort study of all women who were diagnosed with primary CMV infection during pregnancy in a single university affiliated tertiary medical center, between 2012 and 2016. We examined congenital CMV infection and disease rates among infants born to women with and without CMV urinary excretion. Results Overall, 126 women were included, 77 in the positive urinary excretion group, and 49 in the negative urinary excretion group. There was no difference in maternal symptoms between the groups. We found no difference in congenital CMV infection and disease rates between infants born to women with and without urinary excretion of CMV (congenital infection rate 37.1% vs. 24.4%, p = 0.209, congenital disease rate of 18.2% vs. 22.4%, p = 0.648). Women with positive urinary CMV excretion had lower IgG avidity values (36.7% vs 54.6%, p = 0.007), with no additional difference in serology pattern. Compared to asymptomatic women, those with CMV related symptoms did not have significantly higher rates of urinary excretion of CMV (70% vs. 60.5%, p = 0.38) or congenital infection rates (40.7% vs. 31.2%, p = 0.48). Conclusion Among infants of women with primary CMV infection in pregnancy, we did not find an association between urinary excretion of CMV and congenital CMV infection.
format	article
author	Rita Zlatkin Efraim Bilavsky Joseph Pardo Lina Salman Ron Bardin Eran Hadar Anat Shmueli
author_facet	Rita Zlatkin Efraim Bilavsky Joseph Pardo Lina Salman Ron Bardin Eran Hadar Anat Shmueli
author_sort	Rita Zlatkin
title	The association between maternal cytomegalovirus urinary excretion and congenital infection rate
title_short	The association between maternal cytomegalovirus urinary excretion and congenital infection rate
title_full	The association between maternal cytomegalovirus urinary excretion and congenital infection rate
title_fullStr	The association between maternal cytomegalovirus urinary excretion and congenital infection rate
title_full_unstemmed	The association between maternal cytomegalovirus urinary excretion and congenital infection rate
title_sort	association between maternal cytomegalovirus urinary excretion and congenital infection rate
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5bd687c3f37240109c317bee28db260b
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The association between maternal cytomegalovirus urinary excretion and congenital infection rate

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