Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *...

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Autores principales:	Chen H, Liu Y, Huang G, Zhu J, Feng W, He J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	vitamin D cognitive impairment ischemic stroke the Mini-Mental State Examination Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5bd988dbfc3743dfb295caf6872a14de
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id	oai:doaj.org-article:5bd988dbfc3743dfb295caf6872a14de
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spelling	oai:doaj.org-article:5bd988dbfc3743dfb295caf6872a14de2021-12-02T02:21:57ZAssociation between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study1178-1998https://doaj.org/article/5bd988dbfc3743dfb295caf6872a14de2018-12-01T00:00:00Zhttps://www.dovepress.com/association-between-vitamin-d-status-and-cognitive-impairment-in-acute-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels. Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients. Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment. Keywords: vitamin D, cognitive impairment, ischemic stroke, Mini-Mental State ExaminationChen HLiu YHuang GZhu JFeng WHe JDove Medical Pressarticlevitamin Dcognitive impairmentischemic strokethe Mini-Mental State ExaminationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 2503-2509 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D cognitive impairment ischemic stroke the Mini-Mental State Examination Geriatrics RC952-954.6
spellingShingle	vitamin D cognitive impairment ischemic stroke the Mini-Mental State Examination Geriatrics RC952-954.6 Chen H Liu Y Huang G Zhu J Feng W He J Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
description	Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels. Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients. Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment. Keywords: vitamin D, cognitive impairment, ischemic stroke, Mini-Mental State Examination
format	article
author	Chen H Liu Y Huang G Zhu J Feng W He J
author_facet	Chen H Liu Y Huang G Zhu J Feng W He J
author_sort	Chen H
title	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
title_short	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
title_full	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
title_fullStr	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
title_full_unstemmed	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
title_sort	association between vitamin d status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5bd988dbfc3743dfb295caf6872a14de
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Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

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