Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mojgan Alishiri, Sina Ebrahimi, Amir Shamloo, Ahmad Boroumand, Mohammad R. K. Mofrad
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	targeted drug delivery microbubble nanoliposome magnetic targeting ultrasound targeting Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/5bd9a7294cfc4e1a865012a35658fed7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5bd9a7294cfc4e1a865012a35658fed7
record_format	dspace
spelling	oai:doaj.org-article:5bd9a7294cfc4e1a865012a35658fed72021-11-04T15:00:43ZDrug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields1994-20601997-003X10.1080/19942060.2021.1989042https://doaj.org/article/5bd9a7294cfc4e1a865012a35658fed72021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19942060.2021.1989042https://doaj.org/toc/1994-2060https://doaj.org/toc/1997-003XThe use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ $ 121\textrm{\%} $ and ∼ $ 94\textrm{\%} $ , respectively. A focused transducer at the power of $ 60\textrm{W} $ led to better drug delivery performance and caused ∼ $ 67\textrm{\%} $ and ∼ $ 58\textrm{\%} $ enhancement in the surface density of nanoliposomes and MBs adhered to the plaque, respectively. Better drug delivery efficiency was achieved upon using a magnetic field as compared with the ultrasound field. The simultaneous employment of magnetic and ultrasound fields can increase the delivery of nanoliposomes and MBs by ∼ $ 148\textrm{\%} $ and ∼ $ 121\textrm{\%} $ , respectively. The results of this study can broaden our insight on the effects of a magnet (its size, location, and arrangement) and the type of ultrasound transducer on TDD to the carotid artery disease using nanoliposomes and MBs.Mojgan AlishiriSina EbrahimiAmir ShamlooAhmad BoroumandMohammad R. K. MofradTaylor & Francis Grouparticletargeted drug deliverymicrobubblenanoliposomemagnetic targetingultrasound targetingEngineering (General). Civil engineering (General)TA1-2040ENEngineering Applications of Computational Fluid Mechanics, Vol 15, Iss 1, Pp 1703-1725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	targeted drug delivery microbubble nanoliposome magnetic targeting ultrasound targeting Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	targeted drug delivery microbubble nanoliposome magnetic targeting ultrasound targeting Engineering (General). Civil engineering (General) TA1-2040 Mojgan Alishiri Sina Ebrahimi Amir Shamloo Ahmad Boroumand Mohammad R. K. Mofrad Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
description	The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ $ 121\textrm{\%} $ and ∼ $ 94\textrm{\%} $ , respectively. A focused transducer at the power of $ 60\textrm{W} $ led to better drug delivery performance and caused ∼ $ 67\textrm{\%} $ and ∼ $ 58\textrm{\%} $ enhancement in the surface density of nanoliposomes and MBs adhered to the plaque, respectively. Better drug delivery efficiency was achieved upon using a magnetic field as compared with the ultrasound field. The simultaneous employment of magnetic and ultrasound fields can increase the delivery of nanoliposomes and MBs by ∼ $ 148\textrm{\%} $ and ∼ $ 121\textrm{\%} $ , respectively. The results of this study can broaden our insight on the effects of a magnet (its size, location, and arrangement) and the type of ultrasound transducer on TDD to the carotid artery disease using nanoliposomes and MBs.
format	article
author	Mojgan Alishiri Sina Ebrahimi Amir Shamloo Ahmad Boroumand Mohammad R. K. Mofrad
author_facet	Mojgan Alishiri Sina Ebrahimi Amir Shamloo Ahmad Boroumand Mohammad R. K. Mofrad
author_sort	Mojgan Alishiri
title	Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
title_short	Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
title_full	Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
title_fullStr	Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
title_full_unstemmed	Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
title_sort	drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5bd9a7294cfc4e1a865012a35658fed7
work_keys_str_mv	AT mojganalishiri drugdeliveryandadhesionofmagneticnanoparticlescoatednanoliposomesandmicrobubblestoatheroscleroticplaquesundermagneticandultrasoundfields AT sinaebrahimi drugdeliveryandadhesionofmagneticnanoparticlescoatednanoliposomesandmicrobubblestoatheroscleroticplaquesundermagneticandultrasoundfields AT amirshamloo drugdeliveryandadhesionofmagneticnanoparticlescoatednanoliposomesandmicrobubblestoatheroscleroticplaquesundermagneticandultrasoundfields AT ahmadboroumand drugdeliveryandadhesionofmagneticnanoparticlescoatednanoliposomesandmicrobubblestoatheroscleroticplaquesundermagneticandultrasoundfields AT mohammadrkmofrad drugdeliveryandadhesionofmagneticnanoparticlescoatednanoliposomesandmicrobubblestoatheroscleroticplaquesundermagneticandultrasoundfields
_version_	1718444772219158528

Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields

Ejemplares similares