Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine

Exosomes are the master transporters of genes, RNAs, microRNAs, proteins, and lipids. They have applications in major diseases, including cancer, cardiovascular diseases, neurological disorders, and diabetes mellitus. Delivery of the exosomes to recipient cells is governed by the functional heteroge...

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Autores principales:	Madhyastha Harishkumar, Madhyastha Radha, Nakajima Yuichi, Gothandam Kodiveri Muthukalianan, Ohe Kaoru, Koichiro Shiomori, Kentaro Sakai, Watanabe Nozomi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	exosome microvesicles cell engineering regenerative disease Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5bd9ccb6da3e4f3fb51aed1a0c725779
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id	oai:doaj.org-article:5bd9ccb6da3e4f3fb51aed1a0c725779
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spelling	oai:doaj.org-article:5bd9ccb6da3e4f3fb51aed1a0c7257792021-11-25T16:46:25ZDesigner Exosomes: Smart Nano-Communication Tools for Translational Medicine10.3390/bioengineering81101582306-5354https://doaj.org/article/5bd9ccb6da3e4f3fb51aed1a0c7257792021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/158https://doaj.org/toc/2306-5354Exosomes are the master transporters of genes, RNAs, microRNAs, proteins, and lipids. They have applications in major diseases, including cancer, cardiovascular diseases, neurological disorders, and diabetes mellitus. Delivery of the exosomes to recipient cells is governed by the functional heterogenicity of the tissues. Engineered exosomes are promising tools in tissue regeneration. In addition to their role as intracellular communication cargos, exosomes are increasingly primed as standard biomarkers in the progression of diseases, thereby solving the diagnostic dilemma. Futuristic empowerment of exosomes with OMICS strategy can undoubtedly be a bio-tool in translational medicine. This review discusses the advent transformation of exosomes in regenerative medicine and limitations that are caveats to broader applications in clinical use.Madhyastha HarishkumarMadhyastha RadhaNakajima YuichiGothandam Kodiveri MuthukaliananOhe KaoruKoichiro ShiomoriKentaro SakaiWatanabe NozomiMDPI AGarticleexosomemicrovesiclescell engineeringregenerative diseaseTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 158, p 158 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosome microvesicles cell engineering regenerative disease Technology T Biology (General) QH301-705.5
spellingShingle	exosome microvesicles cell engineering regenerative disease Technology T Biology (General) QH301-705.5 Madhyastha Harishkumar Madhyastha Radha Nakajima Yuichi Gothandam Kodiveri Muthukalianan Ohe Kaoru Koichiro Shiomori Kentaro Sakai Watanabe Nozomi Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
description	Exosomes are the master transporters of genes, RNAs, microRNAs, proteins, and lipids. They have applications in major diseases, including cancer, cardiovascular diseases, neurological disorders, and diabetes mellitus. Delivery of the exosomes to recipient cells is governed by the functional heterogenicity of the tissues. Engineered exosomes are promising tools in tissue regeneration. In addition to their role as intracellular communication cargos, exosomes are increasingly primed as standard biomarkers in the progression of diseases, thereby solving the diagnostic dilemma. Futuristic empowerment of exosomes with OMICS strategy can undoubtedly be a bio-tool in translational medicine. This review discusses the advent transformation of exosomes in regenerative medicine and limitations that are caveats to broader applications in clinical use.
format	article
author	Madhyastha Harishkumar Madhyastha Radha Nakajima Yuichi Gothandam Kodiveri Muthukalianan Ohe Kaoru Koichiro Shiomori Kentaro Sakai Watanabe Nozomi
author_facet	Madhyastha Harishkumar Madhyastha Radha Nakajima Yuichi Gothandam Kodiveri Muthukalianan Ohe Kaoru Koichiro Shiomori Kentaro Sakai Watanabe Nozomi
author_sort	Madhyastha Harishkumar
title	Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
title_short	Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
title_full	Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
title_fullStr	Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
title_full_unstemmed	Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine
title_sort	designer exosomes: smart nano-communication tools for translational medicine
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5bd9ccb6da3e4f3fb51aed1a0c725779
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Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine

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