Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats

Abstract The present study aimed to investigate the effects of vitamin D3 (Vit D) administration on memory function, hippocampal level of amyloid-beta (Aβ), brain-derived neurotrophic factor (BDNF) and oxidative stress status in a rat model of unpredictable chronic mild stress (UCMS). Vit D was intr...

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Autores principales:	Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare, Elham Asgari Hassanlouei, Hossein Dinpanah, S. Mohammad Ahmadi-Soleimani, Farimah Beheshti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bda77d2c39447c9b77db3bbc9b4a88c
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spelling	oai:doaj.org-article:5bda77d2c39447c9b77db3bbc9b4a88c2021-12-02T15:07:47ZVitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats10.1038/s41598-021-95850-62045-2322https://doaj.org/article/5bda77d2c39447c9b77db3bbc9b4a88c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95850-6https://doaj.org/toc/2045-2322Abstract The present study aimed to investigate the effects of vitamin D3 (Vit D) administration on memory function, hippocampal level of amyloid-beta (Aβ), brain-derived neurotrophic factor (BDNF) and oxidative stress status in a rat model of unpredictable chronic mild stress (UCMS). Vit D was intraperitoneally administered at doses of 100, 1000, and 10,000 IU/kg. Animals were subjected to UCMS for a total period of 4 weeks. Memory function was assessed using morris water maze (MWM) and passive avoidance (PA) tests. Biochemical markers were measured to reveal the status of oxidative stress and antioxidant defense system. In addition, the levels of Aβ and BDNF were measured in hippocampal region. In the UCMS group, latency to find the platform was greater and the time spent in target quadrant (MWM test) as well as the latency to enter the dark compartment (PA test), were less than the vehicle group. Hippocampal malondialdehyde (MDA) and Aβ concentrations in the UCMS group were higher than the vehicle group. Hippocampal level of thiol and BDNF plus the activities of catalase and superoxide dismutase (SOD) were reduced in UCMS group compared to the control subjects (i.e. vehicle group). Interestingly, Vit D treatment supplementation reversed the mentioned effects of UCMS. Our findings indicated that Vit D administration improves UCMS-induced impairment of learning and memory through prevention of adverse effects on Aβ, BDNF and oxidative stress parameters.Hossein Bakhtiari-DovvombaygiSaeed IzadiMostafa ZareElham Asgari HassanloueiHossein DinpanahS. Mohammad Ahmadi-SoleimaniFarimah BeheshtiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hossein Bakhtiari-Dovvombaygi Saeed Izadi Mostafa Zare Elham Asgari Hassanlouei Hossein Dinpanah S. Mohammad Ahmadi-Soleimani Farimah Beheshti Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
description	Abstract The present study aimed to investigate the effects of vitamin D3 (Vit D) administration on memory function, hippocampal level of amyloid-beta (Aβ), brain-derived neurotrophic factor (BDNF) and oxidative stress status in a rat model of unpredictable chronic mild stress (UCMS). Vit D was intraperitoneally administered at doses of 100, 1000, and 10,000 IU/kg. Animals were subjected to UCMS for a total period of 4 weeks. Memory function was assessed using morris water maze (MWM) and passive avoidance (PA) tests. Biochemical markers were measured to reveal the status of oxidative stress and antioxidant defense system. In addition, the levels of Aβ and BDNF were measured in hippocampal region. In the UCMS group, latency to find the platform was greater and the time spent in target quadrant (MWM test) as well as the latency to enter the dark compartment (PA test), were less than the vehicle group. Hippocampal malondialdehyde (MDA) and Aβ concentrations in the UCMS group were higher than the vehicle group. Hippocampal level of thiol and BDNF plus the activities of catalase and superoxide dismutase (SOD) were reduced in UCMS group compared to the control subjects (i.e. vehicle group). Interestingly, Vit D treatment supplementation reversed the mentioned effects of UCMS. Our findings indicated that Vit D administration improves UCMS-induced impairment of learning and memory through prevention of adverse effects on Aβ, BDNF and oxidative stress parameters.
format	article
author	Hossein Bakhtiari-Dovvombaygi Saeed Izadi Mostafa Zare Elham Asgari Hassanlouei Hossein Dinpanah S. Mohammad Ahmadi-Soleimani Farimah Beheshti
author_facet	Hossein Bakhtiari-Dovvombaygi Saeed Izadi Mostafa Zare Elham Asgari Hassanlouei Hossein Dinpanah S. Mohammad Ahmadi-Soleimani Farimah Beheshti
author_sort	Hossein Bakhtiari-Dovvombaygi
title	Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
title_short	Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
title_full	Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
title_fullStr	Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
title_full_unstemmed	Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
title_sort	vitamin d3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bda77d2c39447c9b77db3bbc9b4a88c
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Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats

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