Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma

Abstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear ce...

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Autores principales:	Xiao-Liang Xing, Zhi-Yong Yao, Jialan Ou, Chaoqun Xing, Feng Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	KIRC Ferroptosis lncRNA Prognosis signatures Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/5bde10f48a5b4a76ab2a50d84942b639
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spelling	oai:doaj.org-article:5bde10f48a5b4a76ab2a50d84942b6392021-11-08T11:13:37ZDevelopment and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma10.1186/s12935-021-02284-11475-2867https://doaj.org/article/5bde10f48a5b4a76ab2a50d84942b6392021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02284-1https://doaj.org/toc/1475-2867Abstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear cell carcinoma. Methods RNAseq count data and corresponding clinical information were obtained from the Cancer Genome Atlas database. Lists of ferroptosis-related genes and long non-coding RNAs were obtained from the FerrDb and GENCODE databases, respectively. The candidate prognostic signatures were screened by Cox regression analyses and least absolute shrinkage and selection operator analyses. Results Three ferroptosis-related long non-coding RNAs (DUXAP8, LINC02609, and LUCAT1) were significantly correlated with the overall survival of kidney renal clear cell carcinoma independently. Kidney renal clear cell carcinoma patients with high-risk values displayed worse OS. Meanwhile, the expression of these three ferroptosis-related long non-coding RNAs and their risk scores were significantly correlated with clinicopathological features. Principal component analyses showed that patients with kidney renal clear cell carcinoma have differential risk values were well distinguished by the three ferroptosis-related long non-coding RNAs. Conclusions The present study suggests that the risk assessment model constructed by these three ferroptosis-related long non-coding RNAs could accurately predict the outcome of kidney renal clear cell carcinoma. We also provide a novel perspective for cancer prognosis screening.Xiao-Liang XingZhi-Yong YaoJialan OuChaoqun XingFeng LiBMCarticleKIRCFerroptosislncRNAPrognosis signaturesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	KIRC Ferroptosis lncRNA Prognosis signatures Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	KIRC Ferroptosis lncRNA Prognosis signatures Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
description	Abstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear cell carcinoma. Methods RNAseq count data and corresponding clinical information were obtained from the Cancer Genome Atlas database. Lists of ferroptosis-related genes and long non-coding RNAs were obtained from the FerrDb and GENCODE databases, respectively. The candidate prognostic signatures were screened by Cox regression analyses and least absolute shrinkage and selection operator analyses. Results Three ferroptosis-related long non-coding RNAs (DUXAP8, LINC02609, and LUCAT1) were significantly correlated with the overall survival of kidney renal clear cell carcinoma independently. Kidney renal clear cell carcinoma patients with high-risk values displayed worse OS. Meanwhile, the expression of these three ferroptosis-related long non-coding RNAs and their risk scores were significantly correlated with clinicopathological features. Principal component analyses showed that patients with kidney renal clear cell carcinoma have differential risk values were well distinguished by the three ferroptosis-related long non-coding RNAs. Conclusions The present study suggests that the risk assessment model constructed by these three ferroptosis-related long non-coding RNAs could accurately predict the outcome of kidney renal clear cell carcinoma. We also provide a novel perspective for cancer prognosis screening.
format	article
author	Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li
author_facet	Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li
author_sort	Xiao-Liang Xing
title	Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
title_short	Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
title_full	Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
title_fullStr	Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
title_full_unstemmed	Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
title_sort	development and validation of ferroptosis-related lncrnas prognosis signatures in kidney renal clear cell carcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5bde10f48a5b4a76ab2a50d84942b639
work_keys_str_mv	AT xiaoliangxing developmentandvalidationofferroptosisrelatedlncrnasprognosissignaturesinkidneyrenalclearcellcarcinoma AT zhiyongyao developmentandvalidationofferroptosisrelatedlncrnasprognosissignaturesinkidneyrenalclearcellcarcinoma AT jialanou developmentandvalidationofferroptosisrelatedlncrnasprognosissignaturesinkidneyrenalclearcellcarcinoma AT chaoqunxing developmentandvalidationofferroptosisrelatedlncrnasprognosissignaturesinkidneyrenalclearcellcarcinoma AT fengli developmentandvalidationofferroptosisrelatedlncrnasprognosissignaturesinkidneyrenalclearcellcarcinoma
_version_	1718442334168809472

Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma

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