Magnetic drug delivery effects on tumor growth

Background and objectives: In the magnetic drug targeting (MDT) method, the medication is bonded to magnetic nanoparticles and is directed to the target site applying a magnetic field. This study aimed to provide a mathematical model for exploring the effects of magnetic drug delivery operating para...

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Autores principales:	Soroosh Arshadi, Ahmad Reza Pishevar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Magnetic drug delivery Magnetic drug targeting Tumor growth simulation Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/5bdedcee34664f2c83451bec33ab7fad
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spelling	oai:doaj.org-article:5bdedcee34664f2c83451bec33ab7fad2021-11-20T05:07:44ZMagnetic drug delivery effects on tumor growth2352-914810.1016/j.imu.2021.100789https://doaj.org/article/5bdedcee34664f2c83451bec33ab7fad2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352914821002604https://doaj.org/toc/2352-9148Background and objectives: In the magnetic drug targeting (MDT) method, the medication is bonded to magnetic nanoparticles and is directed to the target site applying a magnetic field. This study aimed to provide a mathematical model for exploring the effects of magnetic drug delivery operating parameters on the therapy success of a glioblastoma tumor. Methods: For this purpose, tumor growth is modeled by partial derivative equations, and the drug motion equation is coupled with tumor growth and magnetism equations. An oscillatory magnetic field is used in the drug targeting scenarios. Here, a parameter study is conducted, and the effectiveness of therapy is evaluated by considering Tumor Volume Index (TVI) as the ratio of tumor volume in magnetic drug delivery to that in conventional chemotherapy. Results: The results show that the efficacy of this therapy is highly dependent on the distribution of the medication in the adjacent tumor tissue. By increasing the frequency of oscillations relative to the initial state, which is considered to be just a period during treatment, TVI reduced to 0.95 followed by the inversion of the process at a certain value. The examination showed that at an optimum particle size that depends on tissue pore size, the TVI reduces to 0.94. Moreover, it was observed that the higher number of treatment cycles diminished TVI to 0.87. Conclusions: This mathematical model evaluates the efficacy of MDT and enables us to improve and optimize MDT techniques in curing brain tumors.Soroosh ArshadiAhmad Reza PishevarElsevierarticleMagnetic drug deliveryMagnetic drug targetingTumor growth simulationComputer applications to medicine. Medical informaticsR858-859.7ENInformatics in Medicine Unlocked, Vol 27, Iss , Pp 100789- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Magnetic drug delivery Magnetic drug targeting Tumor growth simulation Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Magnetic drug delivery Magnetic drug targeting Tumor growth simulation Computer applications to medicine. Medical informatics R858-859.7 Soroosh Arshadi Ahmad Reza Pishevar Magnetic drug delivery effects on tumor growth
description	Background and objectives: In the magnetic drug targeting (MDT) method, the medication is bonded to magnetic nanoparticles and is directed to the target site applying a magnetic field. This study aimed to provide a mathematical model for exploring the effects of magnetic drug delivery operating parameters on the therapy success of a glioblastoma tumor. Methods: For this purpose, tumor growth is modeled by partial derivative equations, and the drug motion equation is coupled with tumor growth and magnetism equations. An oscillatory magnetic field is used in the drug targeting scenarios. Here, a parameter study is conducted, and the effectiveness of therapy is evaluated by considering Tumor Volume Index (TVI) as the ratio of tumor volume in magnetic drug delivery to that in conventional chemotherapy. Results: The results show that the efficacy of this therapy is highly dependent on the distribution of the medication in the adjacent tumor tissue. By increasing the frequency of oscillations relative to the initial state, which is considered to be just a period during treatment, TVI reduced to 0.95 followed by the inversion of the process at a certain value. The examination showed that at an optimum particle size that depends on tissue pore size, the TVI reduces to 0.94. Moreover, it was observed that the higher number of treatment cycles diminished TVI to 0.87. Conclusions: This mathematical model evaluates the efficacy of MDT and enables us to improve and optimize MDT techniques in curing brain tumors.
format	article
author	Soroosh Arshadi Ahmad Reza Pishevar
author_facet	Soroosh Arshadi Ahmad Reza Pishevar
author_sort	Soroosh Arshadi
title	Magnetic drug delivery effects on tumor growth
title_short	Magnetic drug delivery effects on tumor growth
title_full	Magnetic drug delivery effects on tumor growth
title_fullStr	Magnetic drug delivery effects on tumor growth
title_full_unstemmed	Magnetic drug delivery effects on tumor growth
title_sort	magnetic drug delivery effects on tumor growth
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5bdedcee34664f2c83451bec33ab7fad
work_keys_str_mv	AT soroosharshadi magneticdrugdeliveryeffectsontumorgrowth AT ahmadrezapishevar magneticdrugdeliveryeffectsontumorgrowth
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Magnetic drug delivery effects on tumor growth

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