Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications

Varvara Karagkiozaki1,2, Stergios Logothetidis1, Sylvie Lousinian1, George Giannoglou21Physics Department, Laboratory for Thin Films &ndash; Nanosystems and Nanometrology (LTFN); 2Medical School, AHEPA University General Hospital, 1st Cardiology Department, Aristotle University of Thessaloni...

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Autores principales:	Varvara Karagkiozaki, Stergios Logothetidis, Sylvie Lousinian, George Giannoglou
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5be59177bdc34c6ca18448b16fd9f351
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spelling	oai:doaj.org-article:5be59177bdc34c6ca18448b16fd9f3512021-12-02T10:40:26ZImpact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications1176-91141178-2013https://doaj.org/article/5be59177bdc34c6ca18448b16fd9f3512008-10-01T00:00:00Zhttp://www.dovepress.com/impact-of-surface-electric-properties-of-carbon-based-thin-films-on-pl-a2407https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Varvara Karagkiozaki1,2, Stergios Logothetidis1, Sylvie Lousinian1, George Giannoglou21Physics Department, Laboratory for Thin Films &ndash; Nanosystems and Nanometrology (LTFN); 2Medical School, AHEPA University General Hospital, 1st Cardiology Department, Aristotle University of Thessaloniki, GreeceAbstract: Electric surface properties of biomaterials, playing key role to various biointerfacial interactions, were related to hemocompatibility and biosensing phenomena. In this study, the examination of surface electric properties of amorphous hydrogenated carbon thin films (a-C:H) was carried out by means of electrostatic force microscope (EFM) and observation of differences in spatial charge distribution on the surface of the examined films during platelets adhesion was made. The thrombogenic potential of a-C:H thin films developed by&nbsp; agnetron sputtering with &sim;42% sp3 content and hydrogen partial pressure during deposition was evaluated, by in situ observation with atomic force microscope (AFM) of platelets&rsquo; activation and their subsequent adhesion. Platelet-rich plasma drawn from healthy donors was used and semi-contact mode of AFM was applied. Platelets behavior and their correlation with the electric surface properties of the examined a-C:H films by EFM was made for hemocompatibility enhancement and sensing platelets that are less electrical negatively charged and with higher tendency to aggregate and form thrombus. The results are discussed in view of the effect of different deposition conditions of hydrogenated carbon films on their structural and morphological characteristics, surface roughness and electrical properties attributing to different hemocompatibility and sensing aspects.Keywords: amorphous hydrogenated carbon, platelets, thrombogenicity, atomic force microscopy, electric force microscopy, medical applications&nbsp; Varvara KaragkiozakiStergios LogothetidisSylvie LousinianGeorge GiannoglouDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 461-469 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Varvara Karagkiozaki Stergios Logothetidis Sylvie Lousinian George Giannoglou Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
description	Varvara Karagkiozaki1,2, Stergios Logothetidis1, Sylvie Lousinian1, George Giannoglou21Physics Department, Laboratory for Thin Films &ndash; Nanosystems and Nanometrology (LTFN); 2Medical School, AHEPA University General Hospital, 1st Cardiology Department, Aristotle University of Thessaloniki, GreeceAbstract: Electric surface properties of biomaterials, playing key role to various biointerfacial interactions, were related to hemocompatibility and biosensing phenomena. In this study, the examination of surface electric properties of amorphous hydrogenated carbon thin films (a-C:H) was carried out by means of electrostatic force microscope (EFM) and observation of differences in spatial charge distribution on the surface of the examined films during platelets adhesion was made. The thrombogenic potential of a-C:H thin films developed by&nbsp; agnetron sputtering with &sim;42% sp3 content and hydrogen partial pressure during deposition was evaluated, by in situ observation with atomic force microscope (AFM) of platelets&rsquo; activation and their subsequent adhesion. Platelet-rich plasma drawn from healthy donors was used and semi-contact mode of AFM was applied. Platelets behavior and their correlation with the electric surface properties of the examined a-C:H films by EFM was made for hemocompatibility enhancement and sensing platelets that are less electrical negatively charged and with higher tendency to aggregate and form thrombus. The results are discussed in view of the effect of different deposition conditions of hydrogenated carbon films on their structural and morphological characteristics, surface roughness and electrical properties attributing to different hemocompatibility and sensing aspects.Keywords: amorphous hydrogenated carbon, platelets, thrombogenicity, atomic force microscopy, electric force microscopy, medical applications&nbsp;
format	article
author	Varvara Karagkiozaki Stergios Logothetidis Sylvie Lousinian George Giannoglou
author_facet	Varvara Karagkiozaki Stergios Logothetidis Sylvie Lousinian George Giannoglou
author_sort	Varvara Karagkiozaki
title	Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
title_short	Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
title_full	Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
title_fullStr	Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
title_full_unstemmed	Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
title_sort	impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/5be59177bdc34c6ca18448b16fd9f351
work_keys_str_mv	AT varvarakaragkiozaki impactofsurfaceelectricpropertiesofcarbonbasedthinfilmsonplateletsactivationfornanomedicalandnanosensingapplications AT stergioslogothetidis impactofsurfaceelectricpropertiesofcarbonbasedthinfilmsonplateletsactivationfornanomedicalandnanosensingapplications AT sylvielousinian impactofsurfaceelectricpropertiesofcarbonbasedthinfilmsonplateletsactivationfornanomedicalandnanosensingapplications AT georgegiannoglou impactofsurfaceelectricpropertiesofcarbonbasedthinfilmsonplateletsactivationfornanomedicalandnanosensingapplications
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Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications

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