Nanomedicine in cerebral palsy

Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Departm...

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Autores principales:	Balakrishnan B, Nance E, Johnston MV, Kannan R, Kannan S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5beaabc804074cb990a86ff2cf2f863c
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spelling	oai:doaj.org-article:5beaabc804074cb990a86ff2cf2f863c2021-12-02T06:30:30ZNanomedicine in cerebral palsy1176-91141178-2013https://doaj.org/article/5beaabc804074cb990a86ff2cf2f863c2013-11-01T00:00:00Zhttp://www.dovepress.com/nanomedicine-in-cerebral-palsy-a14862https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. Keywords: dendrimer, cerebral palsy, neuroinflammation, nanoparticle, neonatal brain injury, G4OH-PAMAMBalakrishnan BNance EJohnston MVKannan RKannan SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4183-4195 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Balakrishnan B Nance E Johnston MV Kannan R Kannan S Nanomedicine in cerebral palsy
description	Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. Keywords: dendrimer, cerebral palsy, neuroinflammation, nanoparticle, neonatal brain injury, G4OH-PAMAM
format	article
author	Balakrishnan B Nance E Johnston MV Kannan R Kannan S
author_facet	Balakrishnan B Nance E Johnston MV Kannan R Kannan S
author_sort	Balakrishnan B
title	Nanomedicine in cerebral palsy
title_short	Nanomedicine in cerebral palsy
title_full	Nanomedicine in cerebral palsy
title_fullStr	Nanomedicine in cerebral palsy
title_full_unstemmed	Nanomedicine in cerebral palsy
title_sort	nanomedicine in cerebral palsy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/5beaabc804074cb990a86ff2cf2f863c
work_keys_str_mv	AT balakrishnanb nanomedicineincerebralpalsy AT nancee nanomedicineincerebralpalsy AT johnstonmv nanomedicineincerebralpalsy AT kannanr nanomedicineincerebralpalsy AT kannans nanomedicineincerebralpalsy
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Nanomedicine in cerebral palsy

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