Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.

<h4>Objective</h4>Accumulating evidence suggests that amino acids, particularly tryptophan and glutamate, play an important role in the pathology of depression, but prospective epidemiologic data on this issue is scarce. We examined the association between circulating amino acids and the...

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Autores principales:	Takako Miki, Masafumi Eguchi, Takeshi Kochi, Ami Fukunaga, Sanmei Chen, Akiko Nanri, Isamu Kabe, Tetsuya Mizoue
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bec20ed631f4dafb545c6d1a24f2e1c
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spelling	oai:doaj.org-article:5bec20ed631f4dafb545c6d1a24f2e1c2021-12-02T20:17:54ZProspective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.1932-620310.1371/journal.pone.0256337https://doaj.org/article/5bec20ed631f4dafb545c6d1a24f2e1c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256337https://doaj.org/toc/1932-6203<h4>Objective</h4>Accumulating evidence suggests that amino acids, particularly tryptophan and glutamate, play an important role in the pathology of depression, but prospective epidemiologic data on this issue is scarce. We examined the association between circulating amino acids and the risk of depressive symptoms in a Japanese working population.<h4>Methods</h4>Participants were 841 workers who were free from depressive symptoms and provided blood at baseline and completed 3-yr follow-up survey. 30 varieties of amino acid concentrations in serum were measured using liquid chromatography/mass spectrometry. Depressive symptoms were defined using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to calculate the odds ratios of depressive symptoms according to serum amino acids with adjustment for lifestyle factors.<h4>Results</h4>A total of 151 (18.0%) workers were newly identified as having depressive symptoms at the follow-up. Baseline tryptophan and glutamate concentrations in serum were not appreciably associated with the risk of depressive symptoms. Risk of depressive symptoms tended to increase with increasing arginine concentrations; the multivariable-adjusted odds ratio for the highest versus lowest tertile of serum arginine was 1.65 (95% confidence interval: 0.96-2.83; P for trend = 0.07). No clear association was found for other amino acids.<h4>Conclusions</h4>Results of the present study do not support a significant role of circulating amino acids in the development of depressive symptoms among Japanese.Takako MikiMasafumi EguchiTakeshi KochiAmi FukunagaSanmei ChenAkiko NanriIsamu KabeTetsuya MizouePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256337 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takako Miki Masafumi Eguchi Takeshi Kochi Ami Fukunaga Sanmei Chen Akiko Nanri Isamu Kabe Tetsuya Mizoue Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
description	<h4>Objective</h4>Accumulating evidence suggests that amino acids, particularly tryptophan and glutamate, play an important role in the pathology of depression, but prospective epidemiologic data on this issue is scarce. We examined the association between circulating amino acids and the risk of depressive symptoms in a Japanese working population.<h4>Methods</h4>Participants were 841 workers who were free from depressive symptoms and provided blood at baseline and completed 3-yr follow-up survey. 30 varieties of amino acid concentrations in serum were measured using liquid chromatography/mass spectrometry. Depressive symptoms were defined using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to calculate the odds ratios of depressive symptoms according to serum amino acids with adjustment for lifestyle factors.<h4>Results</h4>A total of 151 (18.0%) workers were newly identified as having depressive symptoms at the follow-up. Baseline tryptophan and glutamate concentrations in serum were not appreciably associated with the risk of depressive symptoms. Risk of depressive symptoms tended to increase with increasing arginine concentrations; the multivariable-adjusted odds ratio for the highest versus lowest tertile of serum arginine was 1.65 (95% confidence interval: 0.96-2.83; P for trend = 0.07). No clear association was found for other amino acids.<h4>Conclusions</h4>Results of the present study do not support a significant role of circulating amino acids in the development of depressive symptoms among Japanese.
format	article
author	Takako Miki Masafumi Eguchi Takeshi Kochi Ami Fukunaga Sanmei Chen Akiko Nanri Isamu Kabe Tetsuya Mizoue
author_facet	Takako Miki Masafumi Eguchi Takeshi Kochi Ami Fukunaga Sanmei Chen Akiko Nanri Isamu Kabe Tetsuya Mizoue
author_sort	Takako Miki
title	Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
title_short	Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
title_full	Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
title_fullStr	Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
title_full_unstemmed	Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.
title_sort	prospective study on the association between serum amino acid profiles and depressive symptoms among the japanese working population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5bec20ed631f4dafb545c6d1a24f2e1c
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Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population.

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