The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?

Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages o...

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Autores principales:	Peter D Katsikis, Yvonne M Mueller, François Villinger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5befb8172cdd415c85b43d7c5183e8b9
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spelling	oai:doaj.org-article:5befb8172cdd415c85b43d7c5183e8b92021-11-18T06:03:07ZThe cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?1553-73661553-737410.1371/journal.ppat.1002055https://doaj.org/article/5befb8172cdd415c85b43d7c5183e8b92011-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21852945/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages of HIV and SIV infection can impact viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. This raises the question whether modulating the cytokine environment during acute/early HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review we focus on the kinetics and function of cytokines during acute HIV and SIV infection and how these may impact viral set-point. We also discuss unresolved questions that are essential for our understanding of the role of acute infection cytokines in HIV infection and that, if answered, may suggest novel therapeutic and vaccine strategies to control the worldwide HIV pandemic.Peter D KatsikisYvonne M MuellerFrançois VillingerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 8, p e1002055 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Peter D Katsikis Yvonne M Mueller François Villinger The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
description	Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages of HIV and SIV infection can impact viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. This raises the question whether modulating the cytokine environment during acute/early HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review we focus on the kinetics and function of cytokines during acute HIV and SIV infection and how these may impact viral set-point. We also discuss unresolved questions that are essential for our understanding of the role of acute infection cytokines in HIV infection and that, if answered, may suggest novel therapeutic and vaccine strategies to control the worldwide HIV pandemic.
format	article
author	Peter D Katsikis Yvonne M Mueller François Villinger
author_facet	Peter D Katsikis Yvonne M Mueller François Villinger
author_sort	Peter D Katsikis
title	The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
title_short	The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
title_full	The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
title_fullStr	The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
title_full_unstemmed	The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
title_sort	cytokine network of acute hiv infection: a promising target for vaccines and therapy to reduce viral set-point?
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5befb8172cdd415c85b43d7c5183e8b9
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The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?

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