Phototherapeutic keratectomy for epithelial basement membrane dystrophy

Wen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoper...

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Autores principales:	Lee WS, Lam CK, Manche EE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epithelial Basement Membrane Dystrophy EBMD Phototherapeutic Keratectomy PTK Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5bf16332a1cf4fb3a9c385b4319abd71
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spelling	oai:doaj.org-article:5bf16332a1cf4fb3a9c385b4319abd712021-12-02T01:00:23ZPhototherapeutic keratectomy for epithelial basement membrane dystrophy1177-5483https://doaj.org/article/5bf16332a1cf4fb3a9c385b4319abd712016-12-01T00:00:00Zhttps://www.dovepress.com/phototherapeutic-keratectomy-for-epithelial-basement-membrane-dystroph-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Wen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3−170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed. The primary outcome measure was symptomatic recurrence as measured by erosions or visual complaints >3 months after successful PTK.Results: For eyes with visual disturbances (n=30), preoperative CDVA was ~20/32 (0.24 LogMAR, SD 0.21) and postoperative CDVA was ~20/25 (0.07 LogMAR, SD 0.12; P<0.0001). Twenty-six eyes (86.7%) responded to treatment, with symptomatic recurrence in 6 eyes (23.1%) at an average of 37.7 months (SD 42.8). For eyes with painful erosions (n=29), preoperative CDVA was ~20/25 (0.12, SD 0.19) and postoperative CDVA was ~20/20 (0.05. SD 0.16; P=0.0785). Twenty-three eyes (79.3%) responded to treatment, with symptomatic recurrence in 3 eyes (13.0%) at an average of 9.7 months (SD 1.5). The probability of being recurrence free after a successful treatment for visual disturbances and erosions at 5 years postoperatively was estimated at 83.0% (95% confidence interval 68.7%–97.0%) and 88.0% (95% confidence interval 65.3%–96.6%), respectively.Conclusion: The majority of visual disturbances and painful erosions associated with EBMD respond to PTK. For those with a treatment response, symptomatic relief is maintained over long-term follow-up. Keywords: epithelial basement membrane dystrophy, EBMD, phototherapeutic keratectomy, PTKLee WSLam CKManche EEDove Medical PressarticleEpithelial Basement Membrane DystrophyEBMDPhototherapeutic KeratectomyPTKOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 15-22 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epithelial Basement Membrane Dystrophy EBMD Phototherapeutic Keratectomy PTK Ophthalmology RE1-994
spellingShingle	Epithelial Basement Membrane Dystrophy EBMD Phototherapeutic Keratectomy PTK Ophthalmology RE1-994 Lee WS Lam CK Manche EE Phototherapeutic keratectomy for epithelial basement membrane dystrophy
description	Wen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3−170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed. The primary outcome measure was symptomatic recurrence as measured by erosions or visual complaints >3 months after successful PTK.Results: For eyes with visual disturbances (n=30), preoperative CDVA was ~20/32 (0.24 LogMAR, SD 0.21) and postoperative CDVA was ~20/25 (0.07 LogMAR, SD 0.12; P<0.0001). Twenty-six eyes (86.7%) responded to treatment, with symptomatic recurrence in 6 eyes (23.1%) at an average of 37.7 months (SD 42.8). For eyes with painful erosions (n=29), preoperative CDVA was ~20/25 (0.12, SD 0.19) and postoperative CDVA was ~20/20 (0.05. SD 0.16; P=0.0785). Twenty-three eyes (79.3%) responded to treatment, with symptomatic recurrence in 3 eyes (13.0%) at an average of 9.7 months (SD 1.5). The probability of being recurrence free after a successful treatment for visual disturbances and erosions at 5 years postoperatively was estimated at 83.0% (95% confidence interval 68.7%–97.0%) and 88.0% (95% confidence interval 65.3%–96.6%), respectively.Conclusion: The majority of visual disturbances and painful erosions associated with EBMD respond to PTK. For those with a treatment response, symptomatic relief is maintained over long-term follow-up. Keywords: epithelial basement membrane dystrophy, EBMD, phototherapeutic keratectomy, PTK
format	article
author	Lee WS Lam CK Manche EE
author_facet	Lee WS Lam CK Manche EE
author_sort	Lee WS
title	Phototherapeutic keratectomy for epithelial basement membrane dystrophy
title_short	Phototherapeutic keratectomy for epithelial basement membrane dystrophy
title_full	Phototherapeutic keratectomy for epithelial basement membrane dystrophy
title_fullStr	Phototherapeutic keratectomy for epithelial basement membrane dystrophy
title_full_unstemmed	Phototherapeutic keratectomy for epithelial basement membrane dystrophy
title_sort	phototherapeutic keratectomy for epithelial basement membrane dystrophy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5bf16332a1cf4fb3a9c385b4319abd71
work_keys_str_mv	AT leews phototherapeutickeratectomyforepithelialbasementmembranedystrophy AT lamck phototherapeutickeratectomyforepithelialbasementmembranedystrophy AT mancheee phototherapeutickeratectomyforepithelialbasementmembranedystrophy
_version_	1718403384696897536

Phototherapeutic keratectomy for epithelial basement membrane dystrophy

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