Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus

Abstract We aimed to provide a laboratory basis for differential diagnosis of COVID-19 and severe fever with thrombocytopenia syndrome (SFTS). Clinical data were collected from 32 COVID-19 patients (2019-nCoV group), 31 SFTS patients (SFTS group) and 30 healthy controls (control group). For each gro...

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Autores principales:	Wentao He, Xiaoyi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bf1d4de7e35435cb95e3fe262504856
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spelling	oai:doaj.org-article:5bf1d4de7e35435cb95e3fe2625048562021-12-02T15:39:50ZSignificance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus10.1038/s41598-021-93519-82045-2322https://doaj.org/article/5bf1d4de7e35435cb95e3fe2625048562021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93519-8https://doaj.org/toc/2045-2322Abstract We aimed to provide a laboratory basis for differential diagnosis of COVID-19 and severe fever with thrombocytopenia syndrome (SFTS). Clinical data were collected from 32 COVID-19 patients (2019-nCoV group), 31 SFTS patients (SFTS group) and 30 healthy controls (control group). For each group of hospitalized patients, a retrospective analysis was performed on specific indices, including cytokines, T-lymphocyte subsets, routine blood parameters, C-reactive protein (CRP) and procalcitonin (PCT), and receiver operating characteristic (ROC) curves for the indices revealed the differences among groups. Compared with the 2019-nCoV group, the SFTS group had a significantly and greatly decreased counts of WBC, absolute lymphocyte, PLT and absolute CD4+ T lymphocyte (P < 0.05); the IL-6, TNF-α, D-D and PCT levels of the SFTS group were higher than those of the 2019-nCoV group (P < 0.05). Compared with those of the SFTS group, the CRP and FIB levels of the 2019-nCoV group were greatly increased (P < 0.05). The ROC curves showed that area under the curves (AUCs) for FIB, PLT and TNF-α were greater than 0.85, demonstrating high diagnostic value. At the initial stage of SARS-CoV-2 or SFTS virus infection, PLT, FIB and TNF-α have definitive clinical value for the early and differential diagnosis of these two infections.Wentao HeXiaoyi LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wentao He Xiaoyi Liu Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
description	Abstract We aimed to provide a laboratory basis for differential diagnosis of COVID-19 and severe fever with thrombocytopenia syndrome (SFTS). Clinical data were collected from 32 COVID-19 patients (2019-nCoV group), 31 SFTS patients (SFTS group) and 30 healthy controls (control group). For each group of hospitalized patients, a retrospective analysis was performed on specific indices, including cytokines, T-lymphocyte subsets, routine blood parameters, C-reactive protein (CRP) and procalcitonin (PCT), and receiver operating characteristic (ROC) curves for the indices revealed the differences among groups. Compared with the 2019-nCoV group, the SFTS group had a significantly and greatly decreased counts of WBC, absolute lymphocyte, PLT and absolute CD4+ T lymphocyte (P < 0.05); the IL-6, TNF-α, D-D and PCT levels of the SFTS group were higher than those of the 2019-nCoV group (P < 0.05). Compared with those of the SFTS group, the CRP and FIB levels of the 2019-nCoV group were greatly increased (P < 0.05). The ROC curves showed that area under the curves (AUCs) for FIB, PLT and TNF-α were greater than 0.85, demonstrating high diagnostic value. At the initial stage of SARS-CoV-2 or SFTS virus infection, PLT, FIB and TNF-α have definitive clinical value for the early and differential diagnosis of these two infections.
format	article
author	Wentao He Xiaoyi Liu
author_facet	Wentao He Xiaoyi Liu
author_sort	Wentao He
title	Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
title_short	Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
title_full	Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
title_fullStr	Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
title_full_unstemmed	Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus
title_sort	significance of peripheral blood indexes in differential diagnoses of sars-cov-2 and new bunia virus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bf1d4de7e35435cb95e3fe262504856
work_keys_str_mv	AT wentaohe significanceofperipheralbloodindexesindifferentialdiagnosesofsarscov2andnewbuniavirus AT xiaoyiliu significanceofperipheralbloodindexesindifferentialdiagnosesofsarscov2andnewbuniavirus
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Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virus

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