A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides

The identification of cross-linked peptides at a proteome scale for interactome analyses represents a complex challenge. Here the authors report an efficient and reliable search engine pLink 2 for proteome-scale cross-linking mass spectrometry analyses, and demonstrate how to systematically evaluate...

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Autores principales:	Zhen-Lin Chen, Jia-Ming Meng, Yong Cao, Ji-Li Yin, Run-Qian Fang, Sheng-Bo Fan, Chao Liu, Wen-Feng Zeng, Yue-He Ding, Dan Tan, Long Wu, Wen-Jing Zhou, Hao Chi, Rui-Xiang Sun, Meng-Qiu Dong, Si-Min He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5bf1da56fec7495f8b611bdf3f8aef38
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spelling	oai:doaj.org-article:5bf1da56fec7495f8b611bdf3f8aef382021-12-02T14:39:16ZA high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides10.1038/s41467-019-11337-z2041-1723https://doaj.org/article/5bf1da56fec7495f8b611bdf3f8aef382019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11337-zhttps://doaj.org/toc/2041-1723The identification of cross-linked peptides at a proteome scale for interactome analyses represents a complex challenge. Here the authors report an efficient and reliable search engine pLink 2 for proteome-scale cross-linking mass spectrometry analyses, and demonstrate how to systematically evaluate the credibility of search engines.Zhen-Lin ChenJia-Ming MengYong CaoJi-Li YinRun-Qian FangSheng-Bo FanChao LiuWen-Feng ZengYue-He DingDan TanLong WuWen-Jing ZhouHao ChiRui-Xiang SunMeng-Qiu DongSi-Min HeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen-Lin Chen Jia-Ming Meng Yong Cao Ji-Li Yin Run-Qian Fang Sheng-Bo Fan Chao Liu Wen-Feng Zeng Yue-He Ding Dan Tan Long Wu Wen-Jing Zhou Hao Chi Rui-Xiang Sun Meng-Qiu Dong Si-Min He A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
description	The identification of cross-linked peptides at a proteome scale for interactome analyses represents a complex challenge. Here the authors report an efficient and reliable search engine pLink 2 for proteome-scale cross-linking mass spectrometry analyses, and demonstrate how to systematically evaluate the credibility of search engines.
format	article
author	Zhen-Lin Chen Jia-Ming Meng Yong Cao Ji-Li Yin Run-Qian Fang Sheng-Bo Fan Chao Liu Wen-Feng Zeng Yue-He Ding Dan Tan Long Wu Wen-Jing Zhou Hao Chi Rui-Xiang Sun Meng-Qiu Dong Si-Min He
author_facet	Zhen-Lin Chen Jia-Ming Meng Yong Cao Ji-Li Yin Run-Qian Fang Sheng-Bo Fan Chao Liu Wen-Feng Zeng Yue-He Ding Dan Tan Long Wu Wen-Jing Zhou Hao Chi Rui-Xiang Sun Meng-Qiu Dong Si-Min He
author_sort	Zhen-Lin Chen
title	A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
title_short	A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
title_full	A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
title_fullStr	A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
title_full_unstemmed	A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
title_sort	high-speed search engine plink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5bf1da56fec7495f8b611bdf3f8aef38
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A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides

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