Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time

Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Paul Han,3 Yongtae Jun,1 Dohyung Lim11Department of Mechanical Engineering, Sejong University, Seoul, South Korea; 2Gerontechnology Research Group, Korea Institute of Industrial Technology, Cheonan, South Korea; 3Department of Biomedica...

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Autores principales:	Lee JH, Chun KJ, Kim HS, Kim SH, Han P, Jun Y, Lim D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Osteoarthritis In Vivo Micro–Computed Tomography Trabecular Bone Microarchitectural Characteristics Trabecular Bone Thickness Distribution Trabecular Bone Separation Distribution Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5bf29e4acb94428d91b6afd0f363182d
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spelling	oai:doaj.org-article:5bf29e4acb94428d91b6afd0f363182d2021-12-02T00:33:01ZAlteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time1178-1998https://doaj.org/article/5bf29e4acb94428d91b6afd0f363182d2012-08-01T00:00:00Zhttps://www.dovepress.com/alteration-patterns-of-trabecular-bone-microarchitectural-characterist-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Paul Han,3 Yongtae Jun,1 Dohyung Lim11Department of Mechanical Engineering, Sejong University, Seoul, South Korea; 2Gerontechnology Research Group, Korea Institute of Industrial Technology, Cheonan, South Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, South Korea; 4Department of Bioengineering and Department of Surgery, National University of Singapore, SingaporeAbstract: Information regarding the alteration of trabecular bone microarchitecture, which is one of the important criteria to estimate bone condition, induced by osteoarthritis (OA) is sparse. The current study therefore aimed to identify and quantify patterns of alterations in trabecular bone microarchitectural characteristics at tibial epiphysis induced by OA using in vivo microcomputed tomography. Fourteen 8-week-old female Sprague Dawley rats were randomly divided into control (n = 7) and OA (n = 7) groups. Rats in the OA group were administered monoiodoacetate into the knee-joint cavity. The tibial joints were scanned by in vivo microcomputed tomography at 0, 4, and 8 weeks after administration. Two-way analysis of variance with Tukey’s honestly significant difference post hoc test was carried out for statistical analyses. The results showed that patterns of alterations in the trabecular bone microarchitectural characteristics in the OA group were not different from those in the control group from 0 to 4 weeks (P > 0.05), but differed from 4 to 8 weeks (P < 0.05). In particular, both trabecular bone thickness and trabecular bone separation distributions over time (4–8 weeks) differed significantly (P < 0.05). These findings suggest that the patterns of bone microarchitecture changes brought about by OA should be periodically considered in the diagnosis and management of arthritic symptoms over time. Improved understanding of the alteration pattern on trabecular bone microarchitecture may assist in developing more targeted treatment interventions for OA.Keywords: osteoarthritis, in vivo microcomputed tomography, trabecular bone microarchitectural characteristics, trabecular bone thickness distribution, trabecular bone separation distributionLee JHChun KJKim HSKim SHHan PJun YLim DDove Medical PressarticleOsteoarthritisIn Vivo Micro–Computed TomographyTrabecular Bone Microarchitectural CharacteristicsTrabecular Bone Thickness DistributionTrabecular Bone Separation DistributionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 303-312 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Osteoarthritis In Vivo Micro–Computed Tomography Trabecular Bone Microarchitectural Characteristics Trabecular Bone Thickness Distribution Trabecular Bone Separation Distribution Geriatrics RC952-954.6
spellingShingle	Osteoarthritis In Vivo Micro–Computed Tomography Trabecular Bone Microarchitectural Characteristics Trabecular Bone Thickness Distribution Trabecular Bone Separation Distribution Geriatrics RC952-954.6 Lee JH Chun KJ Kim HS Kim SH Han P Jun Y Lim D Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
description	Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Paul Han,3 Yongtae Jun,1 Dohyung Lim11Department of Mechanical Engineering, Sejong University, Seoul, South Korea; 2Gerontechnology Research Group, Korea Institute of Industrial Technology, Cheonan, South Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, South Korea; 4Department of Bioengineering and Department of Surgery, National University of Singapore, SingaporeAbstract: Information regarding the alteration of trabecular bone microarchitecture, which is one of the important criteria to estimate bone condition, induced by osteoarthritis (OA) is sparse. The current study therefore aimed to identify and quantify patterns of alterations in trabecular bone microarchitectural characteristics at tibial epiphysis induced by OA using in vivo microcomputed tomography. Fourteen 8-week-old female Sprague Dawley rats were randomly divided into control (n = 7) and OA (n = 7) groups. Rats in the OA group were administered monoiodoacetate into the knee-joint cavity. The tibial joints were scanned by in vivo microcomputed tomography at 0, 4, and 8 weeks after administration. Two-way analysis of variance with Tukey’s honestly significant difference post hoc test was carried out for statistical analyses. The results showed that patterns of alterations in the trabecular bone microarchitectural characteristics in the OA group were not different from those in the control group from 0 to 4 weeks (P > 0.05), but differed from 4 to 8 weeks (P < 0.05). In particular, both trabecular bone thickness and trabecular bone separation distributions over time (4–8 weeks) differed significantly (P < 0.05). These findings suggest that the patterns of bone microarchitecture changes brought about by OA should be periodically considered in the diagnosis and management of arthritic symptoms over time. Improved understanding of the alteration pattern on trabecular bone microarchitecture may assist in developing more targeted treatment interventions for OA.Keywords: osteoarthritis, in vivo microcomputed tomography, trabecular bone microarchitectural characteristics, trabecular bone thickness distribution, trabecular bone separation distribution
format	article
author	Lee JH Chun KJ Kim HS Kim SH Han P Jun Y Lim D
author_facet	Lee JH Chun KJ Kim HS Kim SH Han P Jun Y Lim D
author_sort	Lee JH
title	Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
title_short	Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
title_full	Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
title_fullStr	Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
title_full_unstemmed	Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
title_sort	alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/5bf29e4acb94428d91b6afd0f363182d
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_version_	1718403676299591680

Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time

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