COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19

Abstract The COVID-19 pandemic poses a huge problem of public health that requires the implementation of all available means to contrast it, and drugs are one of them. In this context, we observed an unmet need of depicting the continuously evolving scenario of the ongoing drug clinical trials throu...

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Autores principales:	Luca Menestrina, Chiara Cabrelle, Maurizio Recanatini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bf46464ee3b45849c2c2d7b01f62004
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spelling	oai:doaj.org-article:5bf46464ee3b45849c2c2d7b01f620042021-12-02T17:37:41ZCOVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-1910.1038/s41598-021-98812-02045-2322https://doaj.org/article/5bf46464ee3b45849c2c2d7b01f620042021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98812-0https://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic poses a huge problem of public health that requires the implementation of all available means to contrast it, and drugs are one of them. In this context, we observed an unmet need of depicting the continuously evolving scenario of the ongoing drug clinical trials through an easy-to-use, freely accessible online tool. Starting from this consideration, we developed COVIDrugNet ( http://compmedchem.unibo.it/covidrugnet ), a web application that allows users to capture a holistic view and keep up to date on how the clinical drug research is responding to the SARS-CoV-2 infection. Here, we describe the web app and show through some examples how one can explore the whole landscape of medicines in clinical trial for the treatment of COVID-19 and try to probe the consistency of the current approaches with the available biological and pharmacological evidence. We conclude that careful analyses of the COVID-19 drug-target system based on COVIDrugNet can help to understand the biological implications of the proposed drug options, and eventually improve the search for more effective therapies.Luca MenestrinaChiara CabrelleMaurizio RecanatiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luca Menestrina Chiara Cabrelle Maurizio Recanatini COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
description	Abstract The COVID-19 pandemic poses a huge problem of public health that requires the implementation of all available means to contrast it, and drugs are one of them. In this context, we observed an unmet need of depicting the continuously evolving scenario of the ongoing drug clinical trials through an easy-to-use, freely accessible online tool. Starting from this consideration, we developed COVIDrugNet ( http://compmedchem.unibo.it/covidrugnet ), a web application that allows users to capture a holistic view and keep up to date on how the clinical drug research is responding to the SARS-CoV-2 infection. Here, we describe the web app and show through some examples how one can explore the whole landscape of medicines in clinical trial for the treatment of COVID-19 and try to probe the consistency of the current approaches with the available biological and pharmacological evidence. We conclude that careful analyses of the COVID-19 drug-target system based on COVIDrugNet can help to understand the biological implications of the proposed drug options, and eventually improve the search for more effective therapies.
format	article
author	Luca Menestrina Chiara Cabrelle Maurizio Recanatini
author_facet	Luca Menestrina Chiara Cabrelle Maurizio Recanatini
author_sort	Luca Menestrina
title	COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
title_short	COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
title_full	COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
title_fullStr	COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
title_full_unstemmed	COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19
title_sort	covidrugnet: a network-based web tool to investigate the drugs currently in clinical trial to contrast covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bf46464ee3b45849c2c2d7b01f62004
work_keys_str_mv	AT lucamenestrina covidrugnetanetworkbasedwebtooltoinvestigatethedrugscurrentlyinclinicaltrialtocontrastcovid19 AT chiaracabrelle covidrugnetanetworkbasedwebtooltoinvestigatethedrugscurrentlyinclinicaltrialtocontrastcovid19 AT mauriziorecanatini covidrugnetanetworkbasedwebtooltoinvestigatethedrugscurrentlyinclinicaltrialtocontrastcovid19
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COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19

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