Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy

Abstract This study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid canc...

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Autores principales:	Yusuke Iizuka, Tomohiro Katagiri, Minoru Inoue, Kiyonao Nakamura, Takashi Mizowaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5bffcf038d474b3db18428feaa78bbf6
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spelling	oai:doaj.org-article:5bffcf038d474b3db18428feaa78bbf62021-11-14T12:23:18ZComparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy10.1038/s41598-021-01432-x2045-2322https://doaj.org/article/5bffcf038d474b3db18428feaa78bbf62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01432-xhttps://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid cancer. We evaluated 72 sets of planar and SPECT images acquired between February 2017 and December 2018. Simultaneously, we placed a reference 131I capsule next to the patient during image acquisition. We evaluated the correlation between the intensity of the capsule in the images and the capsule dose and estimated the radiation dose at the thyroid bed. The mean capsule dose was 2.14 MBq (range, 0.63–4.31 MBq). The correlation coefficients (p-value) between capsule dose and maximum and mean intensities in both planar and SPECT images were 0.93 (p < 0.01), 0.96 (p < 0.01), 0.60 (p < 0.01), and 0.47 (p < 0.01), respectively. The mean intensities of planar images show the highest correlation coefficients. Based on a regression equation, the average radiation dose in the thyroid bed was 5.9 MBq. In conclusion, planar images reflected the radiation dose more accurately than SPECT images. The regression equation allows to determine the dose in other regions, such as the thyroid bed or sites of distant metastasis.Yusuke IizukaTomohiro KatagiriMinoru InoueKiyonao NakamuraTakashi MizowakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yusuke Iizuka Tomohiro Katagiri Minoru Inoue Kiyonao Nakamura Takashi Mizowaki Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
description	Abstract This study aimed to evaluate the feasibility of quantifying iodine-131 (131I) accumulation in scintigraphy images and compare planar and single-photon emission computed tomography (SPECT) images to estimate 131I radioactivity in patients receiving radioactive iodine therapy for thyroid cancer. We evaluated 72 sets of planar and SPECT images acquired between February 2017 and December 2018. Simultaneously, we placed a reference 131I capsule next to the patient during image acquisition. We evaluated the correlation between the intensity of the capsule in the images and the capsule dose and estimated the radiation dose at the thyroid bed. The mean capsule dose was 2.14 MBq (range, 0.63–4.31 MBq). The correlation coefficients (p-value) between capsule dose and maximum and mean intensities in both planar and SPECT images were 0.93 (p < 0.01), 0.96 (p < 0.01), 0.60 (p < 0.01), and 0.47 (p < 0.01), respectively. The mean intensities of planar images show the highest correlation coefficients. Based on a regression equation, the average radiation dose in the thyroid bed was 5.9 MBq. In conclusion, planar images reflected the radiation dose more accurately than SPECT images. The regression equation allows to determine the dose in other regions, such as the thyroid bed or sites of distant metastasis.
format	article
author	Yusuke Iizuka Tomohiro Katagiri Minoru Inoue Kiyonao Nakamura Takashi Mizowaki
author_facet	Yusuke Iizuka Tomohiro Katagiri Minoru Inoue Kiyonao Nakamura Takashi Mizowaki
author_sort	Yusuke Iizuka
title	Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
title_short	Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
title_full	Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
title_fullStr	Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
title_full_unstemmed	Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
title_sort	comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5bffcf038d474b3db18428feaa78bbf6
work_keys_str_mv	AT yusukeiizuka comparisonbetweenplanarandsinglephotoncomputedtomographyimagesforradiationintensityquantificationiniodine131scintigraphy AT tomohirokatagiri comparisonbetweenplanarandsinglephotoncomputedtomographyimagesforradiationintensityquantificationiniodine131scintigraphy AT minoruinoue comparisonbetweenplanarandsinglephotoncomputedtomographyimagesforradiationintensityquantificationiniodine131scintigraphy AT kiyonaonakamura comparisonbetweenplanarandsinglephotoncomputedtomographyimagesforradiationintensityquantificationiniodine131scintigraphy AT takashimizowaki comparisonbetweenplanarandsinglephotoncomputedtomographyimagesforradiationintensityquantificationiniodine131scintigraphy
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Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy

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