Structure–function insights reveal the human ribosome as a cancer target for antibiotics

The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.

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Autores principales:	Alexander G. Myasnikov, S. Kundhavai Natchiar, Marielle Nebout, Isabelle Hazemann, Véronique Imbert, Heena Khatter, Jean-François Peyron, Bruno P. Klaholz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c015c0b3ce04e609d082a4c3d51b4f2
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spelling	oai:doaj.org-article:5c015c0b3ce04e609d082a4c3d51b4f22021-12-02T16:56:48ZStructure–function insights reveal the human ribosome as a cancer target for antibiotics10.1038/ncomms128562041-1723https://doaj.org/article/5c015c0b3ce04e609d082a4c3d51b4f22016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12856https://doaj.org/toc/2041-1723The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.Alexander G. MyasnikovS. Kundhavai NatchiarMarielle NeboutIsabelle HazemannVéronique ImbertHeena KhatterJean-François PeyronBruno P. KlaholzNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander G. Myasnikov S. Kundhavai Natchiar Marielle Nebout Isabelle Hazemann Véronique Imbert Heena Khatter Jean-François Peyron Bruno P. Klaholz Structure–function insights reveal the human ribosome as a cancer target for antibiotics
description	The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.
format	article
author	Alexander G. Myasnikov S. Kundhavai Natchiar Marielle Nebout Isabelle Hazemann Véronique Imbert Heena Khatter Jean-François Peyron Bruno P. Klaholz
author_facet	Alexander G. Myasnikov S. Kundhavai Natchiar Marielle Nebout Isabelle Hazemann Véronique Imbert Heena Khatter Jean-François Peyron Bruno P. Klaholz
author_sort	Alexander G. Myasnikov
title	Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_short	Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_full	Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_fullStr	Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_full_unstemmed	Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_sort	structure–function insights reveal the human ribosome as a cancer target for antibiotics
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5c015c0b3ce04e609d082a4c3d51b4f2
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Structure–function insights reveal the human ribosome as a cancer target for antibiotics

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