Maintaining and breaking symmetry in homomeric coiled-coil assemblies

Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design of functional proteins; whereas, the absence of β-br...

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Autores principales:	Guto G. Rhys, Christopher W. Wood, Eric J. M. Lang, Adrian J. Mulholland, R. Leo Brady, Andrew R. Thomson, Derek N. Woolfson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f4
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spelling	oai:doaj.org-article:5c02c52e40f94c5bb66b86f6007891f42021-12-02T16:50:10ZMaintaining and breaking symmetry in homomeric coiled-coil assemblies10.1038/s41467-018-06391-y2041-1723https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f42018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06391-yhttps://doaj.org/toc/2041-1723Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design of functional proteins; whereas, the absence of β-branched side chains leads to unusual low-symmetry α-helical bundles.Guto G. RhysChristopher W. WoodEric J. M. LangAdrian J. MulhollandR. Leo BradyAndrew R. ThomsonDerek N. WoolfsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guto G. Rhys Christopher W. Wood Eric J. M. Lang Adrian J. Mulholland R. Leo Brady Andrew R. Thomson Derek N. Woolfson Maintaining and breaking symmetry in homomeric coiled-coil assemblies
description	Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design of functional proteins; whereas, the absence of β-branched side chains leads to unusual low-symmetry α-helical bundles.
format	article
author	Guto G. Rhys Christopher W. Wood Eric J. M. Lang Adrian J. Mulholland R. Leo Brady Andrew R. Thomson Derek N. Woolfson
author_facet	Guto G. Rhys Christopher W. Wood Eric J. M. Lang Adrian J. Mulholland R. Leo Brady Andrew R. Thomson Derek N. Woolfson
author_sort	Guto G. Rhys
title	Maintaining and breaking symmetry in homomeric coiled-coil assemblies
title_short	Maintaining and breaking symmetry in homomeric coiled-coil assemblies
title_full	Maintaining and breaking symmetry in homomeric coiled-coil assemblies
title_fullStr	Maintaining and breaking symmetry in homomeric coiled-coil assemblies
title_full_unstemmed	Maintaining and breaking symmetry in homomeric coiled-coil assemblies
title_sort	maintaining and breaking symmetry in homomeric coiled-coil assemblies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f4
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Maintaining and breaking symmetry in homomeric coiled-coil assemblies

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