Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection

Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection

Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppr...

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Auteurs principaux: Bin Yang, Junpeng Fan, Jia Huang, Ensong Guo, Yu Fu, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Tianyu Qin, Chao He, Zizhuo Wang, Xu Qin, Dianxing Hu, Lixin You, Xi Li, Tian Wang, Peng Wu, Gang Chen, Jianfeng Zhou, Kezhen Li, Chaoyang Sun
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/5c052d51218d4e68bc4f705fd39765ae
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Résumé:Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppression and reduced expression of ribosomal protein genes.

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