Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection

Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppr...

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Autores principales:	Bin Yang, Junpeng Fan, Jia Huang, Ensong Guo, Yu Fu, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Tianyu Qin, Chao He, Zizhuo Wang, Xu Qin, Dianxing Hu, Lixin You, Xi Li, Tian Wang, Peng Wu, Gang Chen, Jianfeng Zhou, Kezhen Li, Chaoyang Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c052d51218d4e68bc4f705fd39765ae
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spelling	oai:doaj.org-article:5c052d51218d4e68bc4f705fd39765ae2021-12-02T14:58:18ZClinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection10.1038/s41467-021-23621-y2041-1723https://doaj.org/article/5c052d51218d4e68bc4f705fd39765ae2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23621-yhttps://doaj.org/toc/2041-1723Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppression and reduced expression of ribosomal protein genes.Bin YangJunpeng FanJia HuangEnsong GuoYu FuSi LiuRourou XiaoChen LiuFunian LuTianyu QinChao HeZizhuo WangXu QinDianxing HuLixin YouXi LiTian WangPeng WuGang ChenJianfeng ZhouKezhen LiChaoyang SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Yang Junpeng Fan Jia Huang Ensong Guo Yu Fu Si Liu Rourou Xiao Chen Liu Funian Lu Tianyu Qin Chao He Zizhuo Wang Xu Qin Dianxing Hu Lixin You Xi Li Tian Wang Peng Wu Gang Chen Jianfeng Zhou Kezhen Li Chaoyang Sun Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
description	Some patients with COVID-19 fail to clear the viral infection quickly, yet our understanding for the underlying immune characteristics is still lacking. Here the authors use single-cell RNA sequencing and other data form such patients to show that persistent infection is associated with immune suppression and reduced expression of ribosomal protein genes.
format	article
author	Bin Yang Junpeng Fan Jia Huang Ensong Guo Yu Fu Si Liu Rourou Xiao Chen Liu Funian Lu Tianyu Qin Chao He Zizhuo Wang Xu Qin Dianxing Hu Lixin You Xi Li Tian Wang Peng Wu Gang Chen Jianfeng Zhou Kezhen Li Chaoyang Sun
author_facet	Bin Yang Junpeng Fan Jia Huang Ensong Guo Yu Fu Si Liu Rourou Xiao Chen Liu Funian Lu Tianyu Qin Chao He Zizhuo Wang Xu Qin Dianxing Hu Lixin You Xi Li Tian Wang Peng Wu Gang Chen Jianfeng Zhou Kezhen Li Chaoyang Sun
author_sort	Bin Yang
title	Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
title_short	Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
title_full	Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
title_fullStr	Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
title_full_unstemmed	Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection
title_sort	clinical and molecular characteristics of covid-19 patients with persistent sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c052d51218d4e68bc4f705fd39765ae
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Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection

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