Surgical treatment of nonalcoholic fatty liver disease in severely obese patients

Steven J Vander Naalt, Juan P Gurria, AiXuan L HoltermanUniversity of Illinois College of Medicine at Peoria, Children's Hospital of Illinois, Department of Surgery/Pediatric Surgery, Peoria, IL, USAAbstract: Obesity is a multi-organ system disease with underlying metabolic abnormalities an...

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Autores principales:	Vander Naalt SJ, Gurria JP, Holterman AXL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/5c06ace4e5504ec8a193f4f0a4dbd1e4
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spelling	oai:doaj.org-article:5c06ace4e5504ec8a193f4f0a4dbd1e42021-12-02T05:54:28ZSurgical treatment of nonalcoholic fatty liver disease in severely obese patients1179-1535https://doaj.org/article/5c06ace4e5504ec8a193f4f0a4dbd1e42014-10-01T00:00:00Zhttp://www.dovepress.com/surgical-treatment-of-nonalcoholic-fatty-liver-disease-in-severely-obe-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535 Steven J Vander Naalt, Juan P Gurria, AiXuan L HoltermanUniversity of Illinois College of Medicine at Peoria, Children's Hospital of Illinois, Department of Surgery/Pediatric Surgery, Peoria, IL, USAAbstract: Obesity is a multi-organ system disease with underlying metabolic abnormalities and chronic systemic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of obesity metabolic dysfunction and its associated cardiovascular- and liver-related morbidities and mortality. Our current understanding of NAFLD pathogenesis, disease characteristics, the role of insulin resistance, chronic inflammation, gut–liver and gut–brain crosstalk and the effectiveness of pharmacotherapy is still evolving. Bariatric surgery significantly improves metabolic and NAFLD histology in severely obese patients, although its positive effects on fibrosis are not universal. Bariatric surgery benefits NAFLD through its metabolic effect on insulin resistance, inflammation, and insulinotropic and anorexinogenic gastrointestinal hormones. Further studies are needed to understand the natural course of NAFLD in severely obese patients and the role of weight loss surgery as a primary treatment for NAFLD.Keywords: NAFLD, severe obesity, bariatric surgeryVander Naalt SJGurria JPHolterman AXLDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2014, Iss default, Pp 103-112 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Vander Naalt SJ Gurria JP Holterman AXL Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
description	Steven J Vander Naalt, Juan P Gurria, AiXuan L HoltermanUniversity of Illinois College of Medicine at Peoria, Children's Hospital of Illinois, Department of Surgery/Pediatric Surgery, Peoria, IL, USAAbstract: Obesity is a multi-organ system disease with underlying metabolic abnormalities and chronic systemic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of obesity metabolic dysfunction and its associated cardiovascular- and liver-related morbidities and mortality. Our current understanding of NAFLD pathogenesis, disease characteristics, the role of insulin resistance, chronic inflammation, gut–liver and gut–brain crosstalk and the effectiveness of pharmacotherapy is still evolving. Bariatric surgery significantly improves metabolic and NAFLD histology in severely obese patients, although its positive effects on fibrosis are not universal. Bariatric surgery benefits NAFLD through its metabolic effect on insulin resistance, inflammation, and insulinotropic and anorexinogenic gastrointestinal hormones. Further studies are needed to understand the natural course of NAFLD in severely obese patients and the role of weight loss surgery as a primary treatment for NAFLD.Keywords: NAFLD, severe obesity, bariatric surgery
format	article
author	Vander Naalt SJ Gurria JP Holterman AXL
author_facet	Vander Naalt SJ Gurria JP Holterman AXL
author_sort	Vander Naalt SJ
title	Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
title_short	Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
title_full	Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
title_fullStr	Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
title_full_unstemmed	Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
title_sort	surgical treatment of nonalcoholic fatty liver disease in severely obese patients
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5c06ace4e5504ec8a193f4f0a4dbd1e4
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Surgical treatment of nonalcoholic fatty liver disease in severely obese patients

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