T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 res...

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Autores principales:	Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi, Holly L. Rosenzweig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79
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spelling	oai:doaj.org-article:5c09fe5a329b4c398f56c7642549fe792021-12-02T14:40:53ZT cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis10.1038/s41467-020-18961-02041-1723https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe792020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18961-0https://doaj.org/toc/2041-1723How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.Ruth J. NapierEllen J. LeeMichael P. DaveyEmily E. VanceJoão M. FurtadoPaige E. SnowKimberly A. SamsonSydney J. LashleyBrieanna R. BrownReiko HoraiMary J. MattapallilBiying XuMichelle C. CalleganLuke S. UebelhoerChristina L. LancioniRichard K. VeheBryce A. BinstadtJustine R. SmithRachel R. CaspiHolly L. RosenzweigNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruth J. Napier Ellen J. Lee Michael P. Davey Emily E. Vance João M. Furtado Paige E. Snow Kimberly A. Samson Sydney J. Lashley Brieanna R. Brown Reiko Horai Mary J. Mattapallil Biying Xu Michelle C. Callegan Luke S. Uebelhoer Christina L. Lancioni Richard K. Vehe Bryce A. Binstadt Justine R. Smith Rachel R. Caspi Holly L. Rosenzweig T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
description	How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.
format	article
author	Ruth J. Napier Ellen J. Lee Michael P. Davey Emily E. Vance João M. Furtado Paige E. Snow Kimberly A. Samson Sydney J. Lashley Brieanna R. Brown Reiko Horai Mary J. Mattapallil Biying Xu Michelle C. Callegan Luke S. Uebelhoer Christina L. Lancioni Richard K. Vehe Bryce A. Binstadt Justine R. Smith Rachel R. Caspi Holly L. Rosenzweig
author_facet	Ruth J. Napier Ellen J. Lee Michael P. Davey Emily E. Vance João M. Furtado Paige E. Snow Kimberly A. Samson Sydney J. Lashley Brieanna R. Brown Reiko Horai Mary J. Mattapallil Biying Xu Michelle C. Callegan Luke S. Uebelhoer Christina L. Lancioni Richard K. Vehe Bryce A. Binstadt Justine R. Smith Rachel R. Caspi Holly L. Rosenzweig
author_sort	Ruth J. Napier
title	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
title_short	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
title_full	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
title_fullStr	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
title_full_unstemmed	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
title_sort	t cell-intrinsic role for nod2 in protection against th17-mediated uveitis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79
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T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

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