IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE

Abstract. The purpose of the present investigation was to study the immune status of the patients with acute stroke (54 patients with cerebral infarction; 34 — with cerebral hemorrhage). Evaluation of the immune status included the study of the population and subpopulation composition of the periphe...

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Autores principales:	L. N. Kashayeva, L. M. Karzakova, V. N. Saperov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	acute stroke immune status cellular immunodeficiency roncoleukin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5c0c9f8389854eafba28dfff850d1881
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spelling	oai:doaj.org-article:5c0c9f8389854eafba28dfff850d18812021-11-18T08:03:41ZIMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE1563-06252313-741X10.15789/1563-0625-2005-1-57-62https://doaj.org/article/5c0c9f8389854eafba28dfff850d18812014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/425https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The purpose of the present investigation was to study the immune status of the patients with acute stroke (54 patients with cerebral infarction; 34 — with cerebral hemorrhage). Evaluation of the immune status included the study of the population and subpopulation composition of the peripheral blood lymphocytes by means of an indirect immunofluorescent method using monoclonal antibodies CD3, CD4, CD8, CD16, CD20, CD25, CD71, CD95, the determination of IgM, IgG, IgA , circulating immune complexes levels, investigation of neutrophil phagocytic activity. It was shown that the patients with stroke have the obvious suppression of Т–cell mediated immunity and the decrease of the neutrophil phagocytic activity as well as hyperactivation of humoral immunity. 30 patients received immunity modulator twice: repeated subcutaneous injection of roncoleukin (500000 IU) at intervals of 72 hours. The administration of roncoleukin resulted in the increase of T–cell immune response. Moreover, the restoration process of the neurologic functions became quicker. The number of infectious complications, pneumonia particularly, as well as the frequency of lethal outcomes was decreased. (Med. Immunol., 2005, vol.7, № 1, pp. 57562)L. N. KashayevaL. M. KarzakovaV. N. SaperovSPb RAACIarticleacute strokeimmune statuscellular immunodeficiencyroncoleukinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 57-62 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	acute stroke immune status cellular immunodeficiency roncoleukin Immunologic diseases. Allergy RC581-607
spellingShingle	acute stroke immune status cellular immunodeficiency roncoleukin Immunologic diseases. Allergy RC581-607 L. N. Kashayeva L. M. Karzakova V. N. Saperov IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
description	Abstract. The purpose of the present investigation was to study the immune status of the patients with acute stroke (54 patients with cerebral infarction; 34 — with cerebral hemorrhage). Evaluation of the immune status included the study of the population and subpopulation composition of the peripheral blood lymphocytes by means of an indirect immunofluorescent method using monoclonal antibodies CD3, CD4, CD8, CD16, CD20, CD25, CD71, CD95, the determination of IgM, IgG, IgA , circulating immune complexes levels, investigation of neutrophil phagocytic activity. It was shown that the patients with stroke have the obvious suppression of Т–cell mediated immunity and the decrease of the neutrophil phagocytic activity as well as hyperactivation of humoral immunity. 30 patients received immunity modulator twice: repeated subcutaneous injection of roncoleukin (500000 IU) at intervals of 72 hours. The administration of roncoleukin resulted in the increase of T–cell immune response. Moreover, the restoration process of the neurologic functions became quicker. The number of infectious complications, pneumonia particularly, as well as the frequency of lethal outcomes was decreased. (Med. Immunol., 2005, vol.7, № 1, pp. 57562)
format	article
author	L. N. Kashayeva L. M. Karzakova V. N. Saperov
author_facet	L. N. Kashayeva L. M. Karzakova V. N. Saperov
author_sort	L. N. Kashayeva
title	IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
title_short	IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
title_full	IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
title_fullStr	IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
title_full_unstemmed	IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE
title_sort	immune status and its correction in cerebral stroke
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5c0c9f8389854eafba28dfff850d1881
work_keys_str_mv	AT lnkashayeva immunestatusanditscorrectionincerebralstroke AT lmkarzakova immunestatusanditscorrectionincerebralstroke AT vnsaperov immunestatusanditscorrectionincerebralstroke
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IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE

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