The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

Biofilms formed byStaphylococcus aureus are poorly responsive to antibiotics. Here, Siala et al. show that an antifungal drug (caspofungin) enhances the activity of fluoroquinolone antibiotics against S. aureus biofilms by inhibiting an enzyme involved in synthesis of the biofilm matrix.

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Autores principales: Wafi Siala, Soňa Kucharíková, Annabel Braem, Jef Vleugels, Paul M Tulkens, Marie-Paule Mingeot-Leclercq, Patrick Van Dijck, Françoise Van Bambeke
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Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5c0ccbd12ae841e9ad6810f6741185c2
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spelling oai:doaj.org-article:5c0ccbd12ae841e9ad6810f6741185c22021-12-02T16:57:18ZThe antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase10.1038/ncomms132862041-1723https://doaj.org/article/5c0ccbd12ae841e9ad6810f6741185c22016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13286https://doaj.org/toc/2041-1723Biofilms formed byStaphylococcus aureus are poorly responsive to antibiotics. Here, Siala et al. show that an antifungal drug (caspofungin) enhances the activity of fluoroquinolone antibiotics against S. aureus biofilms by inhibiting an enzyme involved in synthesis of the biofilm matrix.Wafi SialaSoňa KucharíkováAnnabel BraemJef VleugelsPaul M TulkensMarie-Paule Mingeot-LeclercqPatrick Van DijckFrançoise Van BambekeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wafi Siala
Soňa Kucharíková
Annabel Braem
Jef Vleugels
Paul M Tulkens
Marie-Paule Mingeot-Leclercq
Patrick Van Dijck
Françoise Van Bambeke
The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
description Biofilms formed byStaphylococcus aureus are poorly responsive to antibiotics. Here, Siala et al. show that an antifungal drug (caspofungin) enhances the activity of fluoroquinolone antibiotics against S. aureus biofilms by inhibiting an enzyme involved in synthesis of the biofilm matrix.
format article
author Wafi Siala
Soňa Kucharíková
Annabel Braem
Jef Vleugels
Paul M Tulkens
Marie-Paule Mingeot-Leclercq
Patrick Van Dijck
Françoise Van Bambeke
author_facet Wafi Siala
Soňa Kucharíková
Annabel Braem
Jef Vleugels
Paul M Tulkens
Marie-Paule Mingeot-Leclercq
Patrick Van Dijck
Françoise Van Bambeke
author_sort Wafi Siala
title The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
title_short The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
title_full The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
title_fullStr The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
title_full_unstemmed The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
title_sort antifungal caspofungin increases fluoroquinolone activity against staphylococcus aureus biofilms by inhibiting n-acetylglucosamine transferase
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/5c0ccbd12ae841e9ad6810f6741185c2
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AT sonakucharikova theantifungalcaspofunginincreasesfluoroquinoloneactivityagainststaphylococcusaureusbiofilmsbyinhibitingnacetylglucosaminetransferase
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