Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

Abstract Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, and biological ch...

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Autores principales:	Jinlong Cao, Jianpeng Li, Xin Yang, Pan Li, Zhiqiang Yao, Dali Han, Lijun Ying, Lijie Wang, Junqiang Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c10249372ee431bb7e701d5550d6642
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spelling	oai:doaj.org-article:5c10249372ee431bb7e701d5550d66422021-12-02T15:23:09ZTranscriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers10.1038/s41598-020-80065-y2045-2322https://doaj.org/article/5c10249372ee431bb7e701d5550d66422021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80065-yhttps://doaj.org/toc/2045-2322Abstract Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, and biological changes in three common urogenital cancers via integrative bioinformatics analysis. First, mRNA (count format) and clinical data for bladder cancer, prostate cancer and renal cell carcinoma were downloaded from the Cancer Genome Atlas (TCGA). Through the comparison of clinicopathological characteristics, genes expression and cells infiltration between the old group and the young group, it was found that the clinical characteristics, genes and cells in the tumor microenvironment of different ages were quite different. And 4 key cells, 14 hub genes and some potential pathways were identified and considered as important factors. More importantly, we analyzed the differential landscape of the genes and cells from different perspectives, and confirmed its importance. In conclusion, we identified genes and cell types associated with age-related changes in the tumour microenvironment in urogenital cancer patients. These genes and cell types may play a critical role in the age-associated differences in clinicopathological characteristics among urogenital cancers, thus providing a link between ageing and cancer occurrence. The findings of this study may pave the way for the development of age-tailored approaches to treat cancer and other age-related diseases.Jinlong CaoJianpeng LiXin YangPan LiZhiqiang YaoDali HanLijun YingLijie WangJunqiang TianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinlong Cao Jianpeng Li Xin Yang Pan Li Zhiqiang Yao Dali Han Lijun Ying Lijie Wang Junqiang Tian Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
description	Abstract Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, and biological changes in three common urogenital cancers via integrative bioinformatics analysis. First, mRNA (count format) and clinical data for bladder cancer, prostate cancer and renal cell carcinoma were downloaded from the Cancer Genome Atlas (TCGA). Through the comparison of clinicopathological characteristics, genes expression and cells infiltration between the old group and the young group, it was found that the clinical characteristics, genes and cells in the tumor microenvironment of different ages were quite different. And 4 key cells, 14 hub genes and some potential pathways were identified and considered as important factors. More importantly, we analyzed the differential landscape of the genes and cells from different perspectives, and confirmed its importance. In conclusion, we identified genes and cell types associated with age-related changes in the tumour microenvironment in urogenital cancer patients. These genes and cell types may play a critical role in the age-associated differences in clinicopathological characteristics among urogenital cancers, thus providing a link between ageing and cancer occurrence. The findings of this study may pave the way for the development of age-tailored approaches to treat cancer and other age-related diseases.
format	article
author	Jinlong Cao Jianpeng Li Xin Yang Pan Li Zhiqiang Yao Dali Han Lijun Ying Lijie Wang Junqiang Tian
author_facet	Jinlong Cao Jianpeng Li Xin Yang Pan Li Zhiqiang Yao Dali Han Lijun Ying Lijie Wang Junqiang Tian
author_sort	Jinlong Cao
title	Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
title_short	Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
title_full	Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
title_fullStr	Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
title_full_unstemmed	Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
title_sort	transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c10249372ee431bb7e701d5550d6642
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Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

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