Transcription activation by a sliding clamp

Transcription activation by a sliding clamp

Transcription activation of late genes in T4 bacteriophage requires the promoter specificity factor gp55, the coactivator gp33 and the sliding clamp gp45. Here, the authors provide structural insights into gp45- dependent transcription activation by determining the cryo-EM structures of a gp55-depen...

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Autores principales: Jing Shi, Aijia Wen, Sha Jin, Bo Gao, Yang Huang, Yu Feng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/5c14ffadb1a3493c9f47cafb37721188
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spelling oai:doaj.org-article:5c14ffadb1a3493c9f47cafb377211882021-12-02T14:03:40ZTranscription activation by a sliding clamp10.1038/s41467-021-21392-02041-1723https://doaj.org/article/5c14ffadb1a3493c9f47cafb377211882021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21392-0https://doaj.org/toc/2041-1723Transcription activation of late genes in T4 bacteriophage requires the promoter specificity factor gp55, the coactivator gp33 and the sliding clamp gp45. Here, the authors provide structural insights into gp45- dependent transcription activation by determining the cryo-EM structures of a gp55-dependent RNA polymerase (RNAP)-promoter open complex and of an intact gp45-dependent transcription activation complex.Jing ShiAijia WenSha JinBo GaoYang HuangYu FengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jing Shi
Aijia Wen
Sha Jin
Bo Gao
Yang Huang
Yu Feng
Transcription activation by a sliding clamp
description Transcription activation of late genes in T4 bacteriophage requires the promoter specificity factor gp55, the coactivator gp33 and the sliding clamp gp45. Here, the authors provide structural insights into gp45- dependent transcription activation by determining the cryo-EM structures of a gp55-dependent RNA polymerase (RNAP)-promoter open complex and of an intact gp45-dependent transcription activation complex.
format article
author Jing Shi
Aijia Wen
Sha Jin
Bo Gao
Yang Huang
Yu Feng
author_facet Jing Shi
Aijia Wen
Sha Jin
Bo Gao
Yang Huang
Yu Feng
author_sort Jing Shi
title Transcription activation by a sliding clamp
title_short Transcription activation by a sliding clamp
title_full Transcription activation by a sliding clamp
title_fullStr Transcription activation by a sliding clamp
title_full_unstemmed Transcription activation by a sliding clamp
title_sort transcription activation by a sliding clamp
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5c14ffadb1a3493c9f47cafb37721188
work_keys_str_mv AT jingshi transcriptionactivationbyaslidingclamp
AT aijiawen transcriptionactivationbyaslidingclamp
AT shajin transcriptionactivationbyaslidingclamp
AT bogao transcriptionactivationbyaslidingclamp
AT yanghuang transcriptionactivationbyaslidingclamp
AT yufeng transcriptionactivationbyaslidingclamp
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