Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

Obesity is associated with low-grade chronic inflammation. Here the authors show that the activation of anti-inflammatory M2a-subtype macrophages requires the IL4/Irs2/Akt pathway. Due to decreased Irs2 expression this pathway is impaired in obese mice thus leading to a defect in M2a activation.

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Autores principales:	Tetsuya Kubota, Mariko Inoue, Naoto Kubota, Iseki Takamoto, Tomoka Mineyama, Kaito Iwayama, Kumpei Tokuyama, Masao Moroi, Kohjiro Ueki, Toshimasa Yamauchi, Takashi Kadowaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c16b774daf24a59904c928896c9f12b
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spelling	oai:doaj.org-article:5c16b774daf24a59904c928896c9f12b2021-12-02T17:32:46ZDownregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity10.1038/s41467-018-07358-92041-1723https://doaj.org/article/5c16b774daf24a59904c928896c9f12b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07358-9https://doaj.org/toc/2041-1723Obesity is associated with low-grade chronic inflammation. Here the authors show that the activation of anti-inflammatory M2a-subtype macrophages requires the IL4/Irs2/Akt pathway. Due to decreased Irs2 expression this pathway is impaired in obese mice thus leading to a defect in M2a activation.Tetsuya KubotaMariko InoueNaoto KubotaIseki TakamotoTomoka MineyamaKaito IwayamaKumpei TokuyamaMasao MoroiKohjiro UekiToshimasa YamauchiTakashi KadowakiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tetsuya Kubota Mariko Inoue Naoto Kubota Iseki Takamoto Tomoka Mineyama Kaito Iwayama Kumpei Tokuyama Masao Moroi Kohjiro Ueki Toshimasa Yamauchi Takashi Kadowaki Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
description	Obesity is associated with low-grade chronic inflammation. Here the authors show that the activation of anti-inflammatory M2a-subtype macrophages requires the IL4/Irs2/Akt pathway. Due to decreased Irs2 expression this pathway is impaired in obese mice thus leading to a defect in M2a activation.
format	article
author	Tetsuya Kubota Mariko Inoue Naoto Kubota Iseki Takamoto Tomoka Mineyama Kaito Iwayama Kumpei Tokuyama Masao Moroi Kohjiro Ueki Toshimasa Yamauchi Takashi Kadowaki
author_facet	Tetsuya Kubota Mariko Inoue Naoto Kubota Iseki Takamoto Tomoka Mineyama Kaito Iwayama Kumpei Tokuyama Masao Moroi Kohjiro Ueki Toshimasa Yamauchi Takashi Kadowaki
author_sort	Tetsuya Kubota
title	Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
title_short	Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
title_full	Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
title_fullStr	Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
title_full_unstemmed	Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
title_sort	downregulation of macrophage irs2 by hyperinsulinemia impairs il-4-indeuced m2a-subtype macrophage activation in obesity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5c16b774daf24a59904c928896c9f12b
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Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

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