Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder

Mehmet Asoglu,1 Mehmet Aslan,2 Okan Imre,1 Yuksel Kivrak,3 Oznur Akil,1 Emin Savik,4 Hasan Buyukaslan,5 Ulker Fedai,1 Abdurrahman Altındag6 1Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, 2Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Va...

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Autores principales:	Asoglu M, Aslan M, Imre O, Kivrak Y, Akil O, Savik E, Buyukaslan H, Fedai U, Altındag A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Panic disorder mean platelet volume red cell distribution width white blood cell count platelet number Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5c174cea77dc433ea9797504f1866f40
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spelling	oai:doaj.org-article:5c174cea77dc433ea9797504f1866f402021-12-02T06:16:22ZMean platelet volume and red cell distribution width levels in initial evaluation of panic disorder1178-2021https://doaj.org/article/5c174cea77dc433ea9797504f1866f402016-09-01T00:00:00Zhttps://www.dovepress.com/mean-platelet-volume-and-red-cell-distribution-width-levels-in-initial-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mehmet Asoglu,1 Mehmet Aslan,2 Okan Imre,1 Yuksel Kivrak,3 Oznur Akil,1 Emin Savik,4 Hasan Buyukaslan,5 Ulker Fedai,1 Abdurrahman Altındag6 1Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, 2Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, 3Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 4Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 5Department of Emergency Medicine, Faculty of Medicine, Harran University, Sanliurfa, 6Department of Psychiatry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Background: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV) in patients with panic disorder (PD) are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW) levels combined with MPV levels in patients with PD.Patients and methods: Between January 2012 and June 2015, data of 30 treatment-naïve patients (16 females, 14 males; mean age: 37±10 years; range: 18–59 years) who were diagnosed with PD and 25 age- and sex-matched healthy volunteers (10 females, 15 males; mean age: 36±13 years; range: 18–59 years) (control group) were retrospectively analyzed. The white blood cell count (WBC), MPV, and RDW levels were measured in both groups.Results: The mean WBC, MPV, and RDW levels were 9,173.03±2,400.31/mm3, 8.19±1.13 fl, and 12.47±1.14%, respectively, in the PD group. These values were found to be 7,090.24±1,032.61, 6.85±0.67, and 11.63±0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0.003, respectively). However, there was no significant difference in the platelet number between the patients with PD and healthy controls (P>0.05).Conclusion: Our study results are the first to demonstrate that the RDW levels combined with MPV levels significantly increase among patients with PD. We believe that increased RDW and MPV levels can be used as a novel marker for PD. Keywords: panic disorder, mean platelet volume, red cell distribution width, white blood cell count, platelet numberAsoglu MAslan MImre OKivrak YAkil OSavik EBuyukaslan HFedai UAltındag ADove Medical PressarticlePanic disordermean platelet volumered cell distribution widthwhite blood cell countplatelet numberNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2435-2438 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Panic disorder mean platelet volume red cell distribution width white blood cell count platelet number Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Panic disorder mean platelet volume red cell distribution width white blood cell count platelet number Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Asoglu M Aslan M Imre O Kivrak Y Akil O Savik E Buyukaslan H Fedai U Altındag A Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
description	Mehmet Asoglu,1 Mehmet Aslan,2 Okan Imre,1 Yuksel Kivrak,3 Oznur Akil,1 Emin Savik,4 Hasan Buyukaslan,5 Ulker Fedai,1 Abdurrahman Altındag6 1Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, 2Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, 3Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 4Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 5Department of Emergency Medicine, Faculty of Medicine, Harran University, Sanliurfa, 6Department of Psychiatry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Background: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV) in patients with panic disorder (PD) are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW) levels combined with MPV levels in patients with PD.Patients and methods: Between January 2012 and June 2015, data of 30 treatment-naïve patients (16 females, 14 males; mean age: 37±10 years; range: 18–59 years) who were diagnosed with PD and 25 age- and sex-matched healthy volunteers (10 females, 15 males; mean age: 36±13 years; range: 18–59 years) (control group) were retrospectively analyzed. The white blood cell count (WBC), MPV, and RDW levels were measured in both groups.Results: The mean WBC, MPV, and RDW levels were 9,173.03±2,400.31/mm3, 8.19±1.13 fl, and 12.47±1.14%, respectively, in the PD group. These values were found to be 7,090.24±1,032.61, 6.85±0.67, and 11.63±0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0.003, respectively). However, there was no significant difference in the platelet number between the patients with PD and healthy controls (P>0.05).Conclusion: Our study results are the first to demonstrate that the RDW levels combined with MPV levels significantly increase among patients with PD. We believe that increased RDW and MPV levels can be used as a novel marker for PD. Keywords: panic disorder, mean platelet volume, red cell distribution width, white blood cell count, platelet number
format	article
author	Asoglu M Aslan M Imre O Kivrak Y Akil O Savik E Buyukaslan H Fedai U Altındag A
author_facet	Asoglu M Aslan M Imre O Kivrak Y Akil O Savik E Buyukaslan H Fedai U Altındag A
author_sort	Asoglu M
title	Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_short	Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_full	Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_fullStr	Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_full_unstemmed	Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_sort	mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5c174cea77dc433ea9797504f1866f40
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Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder

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