Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.

Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a small peptide ring consisting of four amino acids from which two are proteinog...

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Autores principales:	Jouni Jokela, Linn Oftedal, Lars Herfindal, Perttu Permi, Matti Wahlsten, Stein Ove Døskeland, Kaarina Sivonen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c19927631064d42b0af6280785caced
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spelling	oai:doaj.org-article:5c19927631064d42b0af6280785caced2021-11-18T07:11:49ZAnabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.1932-620310.1371/journal.pone.0041222https://doaj.org/article/5c19927631064d42b0af6280785caced2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829929/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a small peptide ring consisting of four amino acids from which two are proteinogenic and two unusual; glycine(1), glycine(2), 2-(3-amino-5-oxytetrahydrofuran-2-yl)-2-hydroxyacetic acid(3) and a long unsaturated C(18) β-amino acid(4) with a conjugated triene structure. They are distinguished by the presence of a conjugated dienic structure in the C18 β-amino acid present in anabaenolysin A but not in anabaenolysin B. Conjugated triene structure generates a typical UV spectrum for anabaenolysins for easy recognition. Anabaenolysin A constituted up to 400 ppm of the cyanobacterial dry weight. We found evidence of thirteen variants of anabaenolysins in one cyanobacterial strain. This suggests that the anabaenolysins are an important class of secondary metabolites in benthic Anabaena cyanobacteria. Both anabaenolysin A and B had cytolytic activity on a number of mammalian cell lines.Jouni JokelaLinn OftedalLars HerfindalPerttu PermiMatti WahlstenStein Ove DøskelandKaarina SivonenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41222 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jouni Jokela Linn Oftedal Lars Herfindal Perttu Permi Matti Wahlsten Stein Ove Døskeland Kaarina Sivonen Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
description	Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a small peptide ring consisting of four amino acids from which two are proteinogenic and two unusual; glycine(1), glycine(2), 2-(3-amino-5-oxytetrahydrofuran-2-yl)-2-hydroxyacetic acid(3) and a long unsaturated C(18) β-amino acid(4) with a conjugated triene structure. They are distinguished by the presence of a conjugated dienic structure in the C18 β-amino acid present in anabaenolysin A but not in anabaenolysin B. Conjugated triene structure generates a typical UV spectrum for anabaenolysins for easy recognition. Anabaenolysin A constituted up to 400 ppm of the cyanobacterial dry weight. We found evidence of thirteen variants of anabaenolysins in one cyanobacterial strain. This suggests that the anabaenolysins are an important class of secondary metabolites in benthic Anabaena cyanobacteria. Both anabaenolysin A and B had cytolytic activity on a number of mammalian cell lines.
format	article
author	Jouni Jokela Linn Oftedal Lars Herfindal Perttu Permi Matti Wahlsten Stein Ove Døskeland Kaarina Sivonen
author_facet	Jouni Jokela Linn Oftedal Lars Herfindal Perttu Permi Matti Wahlsten Stein Ove Døskeland Kaarina Sivonen
author_sort	Jouni Jokela
title	Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
title_short	Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
title_full	Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
title_fullStr	Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
title_full_unstemmed	Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
title_sort	anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5c19927631064d42b0af6280785caced
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Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.

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