Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.

Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely extracellularly, in both the blood and interstitial spaces in tissues. Although most T. brucei research has focused on the biology of bloo...

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Autores principales:	Nathan P Crilly, Monica R Mugnier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5c1acdd66fef48f5bf074dabc5ac1079
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spelling	oai:doaj.org-article:5c1acdd66fef48f5bf074dabc5ac10792021-12-02T20:00:10ZThinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.1553-73661553-737410.1371/journal.ppat.1009866https://doaj.org/article/5c1acdd66fef48f5bf074dabc5ac10792021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009866https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely extracellularly, in both the blood and interstitial spaces in tissues. Although most T. brucei research has focused on the biology of blood- and central nervous system (CNS)-resident parasites, a number of recent studies have highlighted parasite reservoirs in the dermis and adipose tissue, leading to a renewed interest in tissue-resident parasite populations. In light of this renewed interest, work describing tissue-resident parasites can serve as a valuable resource to inform future investigations of tissue-resident T. brucei. Here, we review this body of literature, which describes infections in humans, natural hosts, and experimental animal models, providing a wealth of information on the distribution and biology of extravascular parasites, the corresponding immune response in each tissue, and resulting host pathology. We discuss the implications of these studies and future questions in the study of extravascular T. brucei.Nathan P CrillyMonica R MugnierPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 9, p e1009866 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Nathan P Crilly Monica R Mugnier Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
description	Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely extracellularly, in both the blood and interstitial spaces in tissues. Although most T. brucei research has focused on the biology of blood- and central nervous system (CNS)-resident parasites, a number of recent studies have highlighted parasite reservoirs in the dermis and adipose tissue, leading to a renewed interest in tissue-resident parasite populations. In light of this renewed interest, work describing tissue-resident parasites can serve as a valuable resource to inform future investigations of tissue-resident T. brucei. Here, we review this body of literature, which describes infections in humans, natural hosts, and experimental animal models, providing a wealth of information on the distribution and biology of extravascular parasites, the corresponding immune response in each tissue, and resulting host pathology. We discuss the implications of these studies and future questions in the study of extravascular T. brucei.
format	article
author	Nathan P Crilly Monica R Mugnier
author_facet	Nathan P Crilly Monica R Mugnier
author_sort	Nathan P Crilly
title	Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
title_short	Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
title_full	Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
title_fullStr	Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
title_full_unstemmed	Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.
title_sort	thinking outside the blood: perspectives on tissue-resident trypanosoma brucei.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5c1acdd66fef48f5bf074dabc5ac1079
work_keys_str_mv	AT nathanpcrilly thinkingoutsidethebloodperspectivesontissueresidenttrypanosomabrucei AT monicarmugnier thinkingoutsidethebloodperspectivesontissueresidenttrypanosomabrucei
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Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei.

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