Mitochondrial function controls intestinal epithelial stemness and proliferation

It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a comp...

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Autores principales:	Emanuel Berger, Eva Rath, Detian Yuan, Nadine Waldschmitt, Sevana Khaloian, Michael Allgäuer, Ori Staszewski, Elena M. Lobner, Theresa Schöttl, Pieter Giesbertz, Olivia I. Coleman, Marco Prinz, Achim Weber, Markus Gerhard, Martin Klingenspor, Klaus-Peter Janssen, Mathias Heikenwalder, Dirk Haller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c1d564287fe43ef9426f21f6df2eb1b
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spelling	oai:doaj.org-article:5c1d564287fe43ef9426f21f6df2eb1b2021-12-02T17:33:21ZMitochondrial function controls intestinal epithelial stemness and proliferation10.1038/ncomms131712041-1723https://doaj.org/article/5c1d564287fe43ef9426f21f6df2eb1b2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13171https://doaj.org/toc/2041-1723It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a compensatory release of WNT-related factors.Emanuel BergerEva RathDetian YuanNadine WaldschmittSevana KhaloianMichael AllgäuerOri StaszewskiElena M. LobnerTheresa SchöttlPieter GiesbertzOlivia I. ColemanMarco PrinzAchim WeberMarkus GerhardMartin KlingensporKlaus-Peter JanssenMathias HeikenwalderDirk HallerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emanuel Berger Eva Rath Detian Yuan Nadine Waldschmitt Sevana Khaloian Michael Allgäuer Ori Staszewski Elena M. Lobner Theresa Schöttl Pieter Giesbertz Olivia I. Coleman Marco Prinz Achim Weber Markus Gerhard Martin Klingenspor Klaus-Peter Janssen Mathias Heikenwalder Dirk Haller Mitochondrial function controls intestinal epithelial stemness and proliferation
description	It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a compensatory release of WNT-related factors.
format	article
author	Emanuel Berger Eva Rath Detian Yuan Nadine Waldschmitt Sevana Khaloian Michael Allgäuer Ori Staszewski Elena M. Lobner Theresa Schöttl Pieter Giesbertz Olivia I. Coleman Marco Prinz Achim Weber Markus Gerhard Martin Klingenspor Klaus-Peter Janssen Mathias Heikenwalder Dirk Haller
author_facet	Emanuel Berger Eva Rath Detian Yuan Nadine Waldschmitt Sevana Khaloian Michael Allgäuer Ori Staszewski Elena M. Lobner Theresa Schöttl Pieter Giesbertz Olivia I. Coleman Marco Prinz Achim Weber Markus Gerhard Martin Klingenspor Klaus-Peter Janssen Mathias Heikenwalder Dirk Haller
author_sort	Emanuel Berger
title	Mitochondrial function controls intestinal epithelial stemness and proliferation
title_short	Mitochondrial function controls intestinal epithelial stemness and proliferation
title_full	Mitochondrial function controls intestinal epithelial stemness and proliferation
title_fullStr	Mitochondrial function controls intestinal epithelial stemness and proliferation
title_full_unstemmed	Mitochondrial function controls intestinal epithelial stemness and proliferation
title_sort	mitochondrial function controls intestinal epithelial stemness and proliferation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5c1d564287fe43ef9426f21f6df2eb1b
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Mitochondrial function controls intestinal epithelial stemness and proliferation

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