Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.

<h4>Background</h4>Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC). PB activates nuclear xenobiotic receptor Constitutive Active/Androstane Receptor (CAR; NR1I3) and this activation is shown t...

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Bibliographic Details
Main Authors: Yukio Yamamoto, Rick Moore, Richard A Flavell, Binfeng Lu, Masahiko Negishi
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/5c1ed6f73fa84302a5a8a4d076341aa4
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