Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics

Abstract Feed efficiency (FE) is an important economic indicator in pig production. Improving the FE of commercial pigs is an important strategy for minimizing pig production costs and providing sustainability to the pig industry. In this study, nontargeted LC–MS metabolomics was performed on the co...

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Autores principales:	Yong Ye, Jie Wu, Jianping Quan, Rongrong Ding, Ming Yang, Xingwang Wang, Shenping Zhou, Zhanwei Zhuang, Sixiu Huang, Ting Gu, Lingjun Hong, Enqin Zheng, Zhenfang Wu, Jie Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c260d93eba34f229b877f6d509936f0
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spelling	oai:doaj.org-article:5c260d93eba34f229b877f6d509936f02021-12-02T14:20:34ZLipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics10.1038/s41598-021-87322-82045-2322https://doaj.org/article/5c260d93eba34f229b877f6d509936f02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87322-8https://doaj.org/toc/2045-2322Abstract Feed efficiency (FE) is an important economic indicator in pig production. Improving the FE of commercial pigs is an important strategy for minimizing pig production costs and providing sustainability to the pig industry. In this study, nontargeted LC–MS metabolomics was performed on the contents of the three intestine segments (ileum, cecum and colon) of high-FE and low-FE pigs to explore the effects of small-molecule metabolites in pig intestine on pig FE. A total of 225 Duroc × (Landrace × Yorkshire) pigs in the 30–100 kg stage were sorted based on FE, and 20 pigs with extreme phenotypes were selected, with 10 in each group. A total of 749 metabolites were identified, of which 15, 38 and 11 differed between high-FE and low-FE pigs in ileum, cecum and colon, respectively. These candidate biomarkers mainly comprised lipids and organic acids, which could partially explain the FE difference between the two groups. Among the identified differential metabolites, the lipids are mainly involved in combatting inflammation and oxidation in the ileum and cecum and in bile acid metabolism and vitamin D absorption in the cecum. A difference in organic acids was mainly observed in the hindgut, which is involved in the metabolism of amino acids and fatty acids. This comprehensive study provides new insight into the biochemical mechanisms associated with pig FE.Yong YeJie WuJianping QuanRongrong DingMing YangXingwang WangShenping ZhouZhanwei ZhuangSixiu HuangTing GuLingjun HongEnqin ZhengZhenfang WuJie YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Ye Jie Wu Jianping Quan Rongrong Ding Ming Yang Xingwang Wang Shenping Zhou Zhanwei Zhuang Sixiu Huang Ting Gu Lingjun Hong Enqin Zheng Zhenfang Wu Jie Yang Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
description	Abstract Feed efficiency (FE) is an important economic indicator in pig production. Improving the FE of commercial pigs is an important strategy for minimizing pig production costs and providing sustainability to the pig industry. In this study, nontargeted LC–MS metabolomics was performed on the contents of the three intestine segments (ileum, cecum and colon) of high-FE and low-FE pigs to explore the effects of small-molecule metabolites in pig intestine on pig FE. A total of 225 Duroc × (Landrace × Yorkshire) pigs in the 30–100 kg stage were sorted based on FE, and 20 pigs with extreme phenotypes were selected, with 10 in each group. A total of 749 metabolites were identified, of which 15, 38 and 11 differed between high-FE and low-FE pigs in ileum, cecum and colon, respectively. These candidate biomarkers mainly comprised lipids and organic acids, which could partially explain the FE difference between the two groups. Among the identified differential metabolites, the lipids are mainly involved in combatting inflammation and oxidation in the ileum and cecum and in bile acid metabolism and vitamin D absorption in the cecum. A difference in organic acids was mainly observed in the hindgut, which is involved in the metabolism of amino acids and fatty acids. This comprehensive study provides new insight into the biochemical mechanisms associated with pig FE.
format	article
author	Yong Ye Jie Wu Jianping Quan Rongrong Ding Ming Yang Xingwang Wang Shenping Zhou Zhanwei Zhuang Sixiu Huang Ting Gu Lingjun Hong Enqin Zheng Zhenfang Wu Jie Yang
author_facet	Yong Ye Jie Wu Jianping Quan Rongrong Ding Ming Yang Xingwang Wang Shenping Zhou Zhanwei Zhuang Sixiu Huang Ting Gu Lingjun Hong Enqin Zheng Zhenfang Wu Jie Yang
author_sort	Yong Ye
title	Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
title_short	Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
title_full	Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
title_fullStr	Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
title_full_unstemmed	Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
title_sort	lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by lc–ms-based metabolomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c260d93eba34f229b877f6d509936f0
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Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics

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